Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann, Wouter Koek, Charles P France

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalEuropean Journal of Pharmacology
Volume484
Issue number2-3
DOIs
StatePublished - Jan 26 2004

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Hydroxybutyrates
Baclofen
Food
1,4-butanediol

Keywords

  • γ-GHB (γ-hydroxybutyrate)
  • (±)-Baclofen
  • 1,4-Butanediol
  • Cross-tolerance
  • GABA receptor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Chronic 1,4-butanediol treatment in rats : Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen. / Eckermann, Kary A.; Koek, Wouter; France, Charles P.

In: European Journal of Pharmacology, Vol. 484, No. 2-3, 26.01.2004, p. 259-262.

Research output: Contribution to journalArticle

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