Abstract
The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 259-262 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 484 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Jan 26 2004 |
Fingerprint
Keywords
- γ-GHB (γ-hydroxybutyrate)
- (±)-Baclofen
- 1,4-Butanediol
- Cross-tolerance
- GABA receptor
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Chronic 1,4-butanediol treatment in rats : Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen. / Eckermann, Kary A.; Koek, Wouter; France, Charles P.
In: European Journal of Pharmacology, Vol. 484, No. 2-3, 26.01.2004, p. 259-262.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic 1,4-butanediol treatment in rats
T2 - Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen
AU - Eckermann, Kary A.
AU - Koek, Wouter
AU - France, Charles P
PY - 2004/1/26
Y1 - 2004/1/26
N2 - The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.
AB - The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.
KW - γ-GHB (γ-hydroxybutyrate)
KW - (±)-Baclofen
KW - 1,4-Butanediol
KW - Cross-tolerance
KW - GABA receptor
UR - http://www.scopus.com/inward/record.url?scp=1642505607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1642505607&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2003.11.016
DO - 10.1016/j.ejphar.2003.11.016
M3 - Article
C2 - 14744611
AN - SCOPUS:1642505607
VL - 484
SP - 259
EP - 262
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -