Abstract
The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.
Original language | English (US) |
---|---|
Pages (from-to) | 259-262 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 484 |
Issue number | 2-3 |
DOIs | |
State | Published - Jan 26 2004 |
Keywords
- (±)-Baclofen
- 1,4-Butanediol
- Cross-tolerance
- GABA receptor
- γ-GHB (γ-hydroxybutyrate)
ASJC Scopus subject areas
- Pharmacology