Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann; Wouter Koek; Charles P. France

doi:10.1016/j.ejphar.2003.11.016

Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann, Wouter Koek, Charles P. France

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABA_B mechanisms.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	European Journal of Pharmacology
Volume	484
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ejphar.2003.11.016
State	Published - Jan 26 2004

Keywords

(±)-Baclofen
1,4-Butanediol
Cross-tolerance
GABA receptor
γ-GHB (γ-hydroxybutyrate)

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/j.ejphar.2003.11.016

Fingerprint Dive into the research topics of 'Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen'. Together they form a unique fingerprint.

Cite this

@article{b698a76ea15e4d9fa51c47bc1b7d2548,

title = "Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen",

abstract = "The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.",

keywords = "(±)-Baclofen, 1,4-Butanediol, Cross-tolerance, GABA receptor, γ-GHB (γ-hydroxybutyrate)",

author = "Eckermann, {Kary A.} and Wouter Koek and France, {Charles P.}",

year = "2004",

month = jan,

day = "26",

doi = "10.1016/j.ejphar.2003.11.016",

language = "English (US)",

volume = "484",

pages = "259--262",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "2-3",

}

TY - JOUR

T1 - Chronic 1,4-butanediol treatment in rats

T2 - Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

AU - Eckermann, Kary A.

AU - Koek, Wouter

AU - France, Charles P.

PY - 2004/1/26

Y1 - 2004/1/26

N2 - The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.

AB - The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.

KW - (±)-Baclofen

KW - 1,4-Butanediol

KW - Cross-tolerance

KW - GABA receptor

KW - γ-GHB (γ-hydroxybutyrate)

UR - http://www.scopus.com/inward/record.url?scp=1642505607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642505607&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2003.11.016

DO - 10.1016/j.ejphar.2003.11.016

M3 - Article

C2 - 14744611

AN - SCOPUS:1642505607

VL - 484

SP - 259

EP - 262

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2-3

ER -