Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann; Wouter Koek; Charles P. France

doi:10.1016/j.ejphar.2003.11.016

Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann, Wouter Koek, Charles P. France

Research output: Contribution to journal › Article

11 Scopus citations

Abstract

The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABA_B mechanisms.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	European Journal of Pharmacology
Volume	484
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ejphar.2003.11.016
State	Published - Jan 26 2004

Keywords

(±)-Baclofen
1,4-Butanediol
Cross-tolerance
GABA receptor
γ-GHB (γ-hydroxybutyrate)

ASJC Scopus subject areas

Pharmacology

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Eckermann, K. A., Koek, W., & France, C. P. (2004). Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen. European Journal of Pharmacology, 484(2-3), 259-262. https://doi.org/10.1016/j.ejphar.2003.11.016

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