Chronic 1,4-butanediol treatment in rats: Cross-tolerance to γ-hydroxybutyrate and (±)-baclofen

Kary A. Eckermann, Wouter Koek, Charles P. France

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effects of 1,4-butanediol, γ-hydroxybutyrate (GHB), and (±)-baclofen on food-maintained responding in rats were assessed before, during, and after chronic treatment with 1,4-butanediol. Six weeks of treatment with 1,4-butanediol (twice daily, 320 mg/kg for 3 weeks followed by 560 mg/kg for 3 weeks) decreased sensitivity to the rate-decreasing effects of (±)-baclofen and GHB without changing sensitivity to 1,4-butanediol. Sensitivity to (±)-baclofen and GHB returned to control values 2-3 weeks after discontinuation of treatment. These data suggest that tolerance to the effects of GHB or its precursors might result from changes in GABAB mechanisms.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalEuropean Journal of Pharmacology
Volume484
Issue number2-3
DOIs
StatePublished - Jan 26 2004

Keywords

  • (±)-Baclofen
  • 1,4-Butanediol
  • Cross-tolerance
  • GABA receptor
  • γ-GHB (γ-hydroxybutyrate)

ASJC Scopus subject areas

  • Pharmacology

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