Chromosome damage in untreated tuberculosis patients

V. V.N. Gopal Rao; E. V. Venkatarama Gupta; I. M. Thomas

doi:10.1016/0041-3879(90)90070-O

Chromosome damage in untreated tuberculosis patients

V. V.N. Gopal Rao, E. V. Venkatarama Gupta, I. M. Thomas

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The frequency of chromosomal aberrations and sister chromatid exchanges (SCEs) were estimated in the lymphocytes of 95 untreated tuberculosis patients to evaluate the chromosomal damage with reference to bacterial invasion. The frequency of chromosomal aberrations was significantly higher in tuberculosis patients compared to controls (p < 0.001) while the SCE frequency did not show any statistically significant differences. These findings indicate that the basic mechanism of formation of chromosomal aberrations and SCE are different and they suggest that the tubercle bacillus might be capable of inducing chromosome damage.

Original language	English (US)
Pages (from-to)	169-172
Number of pages	4
Journal	Tubercle
Volume	71
Issue number	3
DOIs	https://doi.org/10.1016/0041-3879(90)90070-O
State	Published - Sep 1990
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/0041-3879(90)90070-O

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@article{06d0906b1ea44c1ea320a85815d89d68,

title = "Chromosome damage in untreated tuberculosis patients",

abstract = "The frequency of chromosomal aberrations and sister chromatid exchanges (SCEs) were estimated in the lymphocytes of 95 untreated tuberculosis patients to evaluate the chromosomal damage with reference to bacterial invasion. The frequency of chromosomal aberrations was significantly higher in tuberculosis patients compared to controls (p < 0.001) while the SCE frequency did not show any statistically significant differences. These findings indicate that the basic mechanism of formation of chromosomal aberrations and SCE are different and they suggest that the tubercle bacillus might be capable of inducing chromosome damage.",

author = "{Gopal Rao}, {V. V.N.} and {Venkatarama Gupta}, {E. V.} and Thomas, {I. M.}",

note = "Funding Information: Part of this work was financially supported by ICMR, New Delhi, and we gratefully acknowledge their assistance. The authors are also grateful to the staff of Lady Wellingdon State Tuberculosis Centre, Bangalore for providing the patients.",

year = "1990",

month = sep,

doi = "10.1016/0041-3879(90)90070-O",

language = "English (US)",

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pages = "169--172",

journal = "Tubercle",

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T1 - Chromosome damage in untreated tuberculosis patients

AU - Gopal Rao, V. V.N.

AU - Venkatarama Gupta, E. V.

AU - Thomas, I. M.

N1 - Funding Information: Part of this work was financially supported by ICMR, New Delhi, and we gratefully acknowledge their assistance. The authors are also grateful to the staff of Lady Wellingdon State Tuberculosis Centre, Bangalore for providing the patients.

PY - 1990/9

Y1 - 1990/9

N2 - The frequency of chromosomal aberrations and sister chromatid exchanges (SCEs) were estimated in the lymphocytes of 95 untreated tuberculosis patients to evaluate the chromosomal damage with reference to bacterial invasion. The frequency of chromosomal aberrations was significantly higher in tuberculosis patients compared to controls (p < 0.001) while the SCE frequency did not show any statistically significant differences. These findings indicate that the basic mechanism of formation of chromosomal aberrations and SCE are different and they suggest that the tubercle bacillus might be capable of inducing chromosome damage.

AB - The frequency of chromosomal aberrations and sister chromatid exchanges (SCEs) were estimated in the lymphocytes of 95 untreated tuberculosis patients to evaluate the chromosomal damage with reference to bacterial invasion. The frequency of chromosomal aberrations was significantly higher in tuberculosis patients compared to controls (p < 0.001) while the SCE frequency did not show any statistically significant differences. These findings indicate that the basic mechanism of formation of chromosomal aberrations and SCE are different and they suggest that the tubercle bacillus might be capable of inducing chromosome damage.

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U2 - 10.1016/0041-3879(90)90070-O

DO - 10.1016/0041-3879(90)90070-O

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AN - SCOPUS:0025032154

SN - 0041-3879

VL - 71

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JO - Tubercle

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ER -

Chromosome damage in untreated tuberculosis patients

Abstract

ASJC Scopus subject areas

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