Chromosome damage in untreated tuberculosis patients

Gopalrao V Velagaleti, E. V. Venkatarama Gupta, I. M. Thomas

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The frequency of chromosomal aberrations and sister chromatid exchanges (SCEs) were estimated in the lymphocytes of 95 untreated tuberculosis patients to evaluate the chromosomal damage with reference to bacterial invasion. The frequency of chromosomal aberrations was significantly higher in tuberculosis patients compared to controls (p < 0.001) while the SCE frequency did not show any statistically significant differences. These findings indicate that the basic mechanism of formation of chromosomal aberrations and SCE are different and they suggest that the tubercle bacillus might be capable of inducing chromosome damage.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalTubercle
Volume71
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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Sister Chromatid Exchange
Chromosome Aberrations
Tuberculosis
Chromosomes
Bacillus
Lymphocytes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Chromosome damage in untreated tuberculosis patients. / Velagaleti, Gopalrao V; Venkatarama Gupta, E. V.; Thomas, I. M.

In: Tubercle, Vol. 71, No. 3, 1990, p. 169-172.

Research output: Contribution to journalArticle

Velagaleti, Gopalrao V ; Venkatarama Gupta, E. V. ; Thomas, I. M. / Chromosome damage in untreated tuberculosis patients. In: Tubercle. 1990 ; Vol. 71, No. 3. pp. 169-172.
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