Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes

Alan Y Sakaguchi, P. A. Lalley, B. U. Zabel, R. W. Ellis, E. M. Scolnick, S. L. Naylor

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number2 I
StatePublished - 1984
Externally publishedYes

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Oncogenes
Sarcoma
Leukemia
Chromosomes
Viruses
Chromosomes, Human, Pair 6
ras Genes
Hybrid Cells
Harvey murine sarcoma virus
Kirsten murine sarcoma virus
Avian Myeloblastosis Virus
Triose-Phosphate Isomerase
Chromosomes, Human, Pair 20
Rous sarcoma virus
Molecular Probes
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 11
Glyceraldehyde-3-Phosphate Dehydrogenases
Chromosomes, Human, Pair 2
DNA

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes. / Sakaguchi, Alan Y; Lalley, P. A.; Zabel, B. U.; Ellis, R. W.; Scolnick, E. M.; Naylor, S. L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, No. 2 I, 1984, p. 525-529.

Research output: Contribution to journalArticle

Sakaguchi, Alan Y ; Lalley, P. A. ; Zabel, B. U. ; Ellis, R. W. ; Scolnick, E. M. ; Naylor, S. L. / Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes. In: Proceedings of the National Academy of Sciences of the United States of America. 1984 ; Vol. 81, No. 2 I. pp. 525-529.
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abstract = "Molecular probes for the oncogenes of Rous sarcoma virus (v-src), avian myeloblastosis virus (v-myb), Kirsten murine sarcoma virus (v-Ki-ras), and Harvey murine sarcoma virus (v-Ha-ras) were hybridized to the DNA from mouse-Chinese hamster somatic cell hybrids. The v-src, v-myb, v-Ki-ras, and v-Ha-ras genes each detected one or a few homologous mouse DNA fragments whose segregation was analyzed in cell hybrids. Mouse cellular homologs c-src, c-Ki-ras, c-Ha-ras, and c-myb segregated concordantly with chromosomes 2, 6, 7, and 10, respectively. Comparison with the known locations of human c-src (chromosome 20) and human c-Ha-ras1 (chromosome 11 short arm) suggests that the human and mouse homologs of these two viral oncogenes reside in conserved linkage groups. The c-Ki-ras gene on mouse chromosome 6 might reside also in a conserved linkage group, along with glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase. However, direct confirmation of this suggestion must await a demonstration that c-Ki-ras on mouse chromosome 6 is homologous to c-Ki-ras2 on the short arm of human chromosome 12.",
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T1 - Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes

AU - Sakaguchi, Alan Y

AU - Lalley, P. A.

AU - Zabel, B. U.

AU - Ellis, R. W.

AU - Scolnick, E. M.

AU - Naylor, S. L.

PY - 1984

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N2 - Molecular probes for the oncogenes of Rous sarcoma virus (v-src), avian myeloblastosis virus (v-myb), Kirsten murine sarcoma virus (v-Ki-ras), and Harvey murine sarcoma virus (v-Ha-ras) were hybridized to the DNA from mouse-Chinese hamster somatic cell hybrids. The v-src, v-myb, v-Ki-ras, and v-Ha-ras genes each detected one or a few homologous mouse DNA fragments whose segregation was analyzed in cell hybrids. Mouse cellular homologs c-src, c-Ki-ras, c-Ha-ras, and c-myb segregated concordantly with chromosomes 2, 6, 7, and 10, respectively. Comparison with the known locations of human c-src (chromosome 20) and human c-Ha-ras1 (chromosome 11 short arm) suggests that the human and mouse homologs of these two viral oncogenes reside in conserved linkage groups. The c-Ki-ras gene on mouse chromosome 6 might reside also in a conserved linkage group, along with glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase. However, direct confirmation of this suggestion must await a demonstration that c-Ki-ras on mouse chromosome 6 is homologous to c-Ki-ras2 on the short arm of human chromosome 12.

AB - Molecular probes for the oncogenes of Rous sarcoma virus (v-src), avian myeloblastosis virus (v-myb), Kirsten murine sarcoma virus (v-Ki-ras), and Harvey murine sarcoma virus (v-Ha-ras) were hybridized to the DNA from mouse-Chinese hamster somatic cell hybrids. The v-src, v-myb, v-Ki-ras, and v-Ha-ras genes each detected one or a few homologous mouse DNA fragments whose segregation was analyzed in cell hybrids. Mouse cellular homologs c-src, c-Ki-ras, c-Ha-ras, and c-myb segregated concordantly with chromosomes 2, 6, 7, and 10, respectively. Comparison with the known locations of human c-src (chromosome 20) and human c-Ha-ras1 (chromosome 11 short arm) suggests that the human and mouse homologs of these two viral oncogenes reside in conserved linkage groups. The c-Ki-ras gene on mouse chromosome 6 might reside also in a conserved linkage group, along with glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase. However, direct confirmation of this suggestion must await a demonstration that c-Ki-ras on mouse chromosome 6 is homologous to c-Ki-ras2 on the short arm of human chromosome 12.

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