Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors

Ling Mei Wang, Ann M. Killary, Xiao En Fang, Sandi K. Parriott, Peter A. Lalley, Graeme I. Bell, Alan Y. Sakaguchi

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Receptors for insulin, low-density lipoprotein, and colony stimulating factor 1 are associated with diabetes, atherosclerosis, and cancer in man. Complementary DNA clones for Insr, Ldlr, and Csfmr were used to chromosomally assign the three genes in mouse. In contrast to their close linkage on the short arm of human Chromosome 19, Insr and Ldlr are asyntenic, residing on mouse Chromosomes 8 and 9, respectively. The genes for CSF1R, CSF1, CSF2, IL-3, and IL-5 form a cluster on the long arm of human Chromosome 5. In mouse, Csfm, Csfgm, and IL-3 are syntenic on Chromosome 11. The Csfmr gene was assigned to mouse Chromosome 18 and is thus unlinked to other members of this gene cluster. These gene assignments provide additional topographical information on conservation of linkage groups in man and mouse and provide a genetic framework for evaluating the possible roles for the three receptor genes in genetic diseases in mouse.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalGenomics
Volume3
Issue number2
DOIs
StatePublished - Aug 1988

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors'. Together they form a unique fingerprint.

  • Cite this