Chromosome 18 suppresses the tumorigenicity of prostate cancer cells

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Microcell-mediated chromosome transfer allows for the introduction of normal chromosomes into tumor cells in an effort to identify putative tumor suppressor genes. We have used this approach to introduce an intact copy of chromosome 18 into the prostate cancer cell line DUI45, and independently to introduce human chromosomes 8 and 18 into the prostate cancer cell line TSU-PRI. Introduction of an extra copy of human chromosome 8 had no effect on the growth properties in vitro or the tumorigenicity in vivo of TSU-PRI cells. However, microcell hybrids containing an introduced copy of human chromosome 18 exhibited a longer population doubling time, retarded growth in soft agar, and slowed tumor growth in athymic nude mice. These experiments provide functional evidence for the presence of one or more tumor suppressor genes on human chromosome 18 that are involved in prostate cancer.

Original languageEnglish (US)
Pages (from-to)221-229
Number of pages9
JournalGenes Chromosomes and Cancer
Volume30
Issue number3
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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