Chromosome 11 abnormalities in Bowen disease of the vulva

Gregory P. Swanson, Sheila M. Dobin, Janet M. Arber, Daniel A. Arber, Charles V. Capen, Jaime A. Diaz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Chromosomal cytogenetic abnormalities are common in tumor cells and are often the basis for more detailed chromosomal mapping of tumor suppressor and oncogenes. Chromosome 11 abnormalities are frequently recognized in various neoplasms. We report a case of Bowen disease (squamous cell carcinoma in situ) of the vulva with an isolated 11p cytogenetic abnormality. A chromosome 11 paint confirmed two copies of chromosome 11 in all analyzed metaphases. An 11p subtelomeric probe confirmed an abnormality of 11p15→pter indicative of a deletion. Previous studies of invasive vulvar cancers also frequently show 11p cytogenetic abnormalities, but never as an isolated finding. The patient suffered from other diseases that may also be related to this locus. Breakage and p53 studies were normal. It is possible that an 11p abnormality in Bowen's disease is a precursor in the evolution of invasive vulva cancer.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume93
Issue number2
DOIs
StatePublished - Feb 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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