Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouse

Alan Y. Sakaguchi, Susan S. Padalecki, Vicki Mattern, Angelica Rodriguez, Robin J. Leach, John R. McGill, Michelle Chavez, Troy A. Giambernardi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Telomere repeat binding factor 2 (TERF2) is one of two recently cloned mammalian telomere binding protein genes. TERF2 binds as a dimer with high affinity to the double-stranded TTAGGG telomeric repeat through an evolutionarily conserved myb-type DNA binding domain. TERF2 prevents telomere end-to-end fusion and may be important in maintaining genomic stability. We localized the transcribed TERF2 gene to human chromosome 16q22.1, tightly linked to the EST HUMOOOS343. The mouse Terf2 gene is situated by itself in a newly defined 'bin' on chromosome 8 one crossover distal to Psm10 and Sntb2. Human TERF2 and mouse Terf2 are therefore part of a large evolutionarily conserved linkage group comprised of at least 25 known paralogous genes between human chromosome 16q and mouse chromosome 8.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalSomatic Cell and Molecular Genetics
Volume24
Issue number3
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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