Chromosomal rearrangement in Candida stellatoidea results in a positive effect on phenotype

B. L. Wickes, J. E. Golin, K. J. Kwon-Chung

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 108 cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phenotypic change only occurs in conjunction with a chromosomal rearrangement. These rearrangements have been studied in a strain naturally marked for methionine auxotrophy. Chromosome-size DNA bands separated by pulsed-field gel electrophoresis were probed with genes cloned from C. albicans. The hybridization pattern indicated that the genes on several chromosomes underwent extensive rearrangement.

Original languageEnglish (US)
Pages (from-to)1762-1771
Number of pages10
JournalInfection and Immunity
Volume59
Issue number5
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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