When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 108 cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phenotypic change only occurs in conjunction with a chromosomal rearrangement. These rearrangements have been studied in a strain naturally marked for methionine auxotrophy. Chromosome-size DNA bands separated by pulsed-field gel electrophoresis were probed with genes cloned from C. albicans. The hybridization pattern indicated that the genes on several chromosomes underwent extensive rearrangement.
|Original language||English (US)|
|Number of pages||10|
|Journal||Infection and Immunity|
|State||Published - Jan 1 1991|
ASJC Scopus subject areas
- Infectious Diseases