Abstract
When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 108 cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phenotypic change only occurs in conjunction with a chromosomal rearrangement. These rearrangements have been studied in a strain naturally marked for methionine auxotrophy. Chromosome-size DNA bands separated by pulsed-field gel electrophoresis were probed with genes cloned from C. albicans. The hybridization pattern indicated that the genes on several chromosomes underwent extensive rearrangement.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1762-1771 |
| Number of pages | 10 |
| Journal | Infection and immunity |
| Volume | 59 |
| Issue number | 5 |
| State | Published - 1991 |
| Externally published | Yes |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases