Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization

J. L. McCombs, C. T. Teng, B. T. Pentecost, V. L. Magnuson, C. M. Moore, J. R. McGill

Research output: Contribution to journalArticle

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Abstract

Lactotransferrin (LTF) is an important member of the transferrin family of proteins. These proteins play an essential role in the transport of iron in extracellular fluid (Aisen and Listowsky, 1980). Southern blot analysis of mouse-human somatic cell hybrids have localized the LTF gene to region q1→qter of human chromosome 3 (Teng et al., unpublished data). Using the same full-length mouse cDNA probe (2.2 kb), the LTF gene was mapped to human chromosomal bands 3q21→q23 by in situ hybridization. The sublocalization of the LTF gene to 3q21→q23 is in the region of human chromosome 3 where the gene loci of transferrin and transferrin receptor have been localized. (Yang et al., 1984; van de Rijn et al., 1983).

Original languageEnglish (US)
Pages (from-to)16-17
Number of pages2
JournalCytogenetics and Cell Genetics
Volume47
Issue number1-2
StatePublished - 1988

Fingerprint

Lactoferrin
In Situ Hybridization
Genes
Chromosomes, Human, Pair 3
Human Chromosomes
Transferrin
Transferrin Receptors
Hybrid Cells
Extracellular Fluid
Southern Blotting
Proteins
Iron
Complementary DNA

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

McCombs, J. L., Teng, C. T., Pentecost, B. T., Magnuson, V. L., Moore, C. M., & McGill, J. R. (1988). Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization. Cytogenetics and Cell Genetics, 47(1-2), 16-17.

Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization. / McCombs, J. L.; Teng, C. T.; Pentecost, B. T.; Magnuson, V. L.; Moore, C. M.; McGill, J. R.

In: Cytogenetics and Cell Genetics, Vol. 47, No. 1-2, 1988, p. 16-17.

Research output: Contribution to journalArticle

McCombs, JL, Teng, CT, Pentecost, BT, Magnuson, VL, Moore, CM & McGill, JR 1988, 'Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization', Cytogenetics and Cell Genetics, vol. 47, no. 1-2, pp. 16-17.
McCombs JL, Teng CT, Pentecost BT, Magnuson VL, Moore CM, McGill JR. Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization. Cytogenetics and Cell Genetics. 1988;47(1-2):16-17.
McCombs, J. L. ; Teng, C. T. ; Pentecost, B. T. ; Magnuson, V. L. ; Moore, C. M. ; McGill, J. R. / Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization. In: Cytogenetics and Cell Genetics. 1988 ; Vol. 47, No. 1-2. pp. 16-17.
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