Chromosomal localization of human lactotransferrin gene (Ltf) by in situ hybridization

J. L. McCombs, C. T. Teng, B. T. Pentecost, V. L. Magnuson, C. M. Moore, J. R. McGill

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Lactotransferrin (LTF) is an important member of the transferrin family of proteins. These proteins play an essential role in the transport of iron in extracellular fluid (Aisen and Lis-towsky. 1980). Southern blot analysis of mouse-human somatic cell hybrids have localized the LTF gene to region q21→qter of human chromosome 3 (Teng et al., unpublished data). Using the same full-length mouse cDNA probe (2.2 kb), the LTF gene was mapped to human chromosomal bands 3q21→q23 by in situ hybridization. The sublocalization of the LTF gene to 3q21→q23 is in the region of human chromosome 3 where the gene loci of transferrin and transferrin receptor have been localized (Yang et al. 1984; van dc Rijn el al. 1983).

Original languageEnglish (US)
Pages (from-to)16-17
Number of pages2
JournalCytogenetic and Genome Research
Volume47
Issue number1-2
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    McCombs, J. L., Teng, C. T., Pentecost, B. T., Magnuson, V. L., Moore, C. M., & McGill, J. R. (1988). Chromosomal localization of human lactotransferrin gene (Ltf) by in situ hybridization. Cytogenetic and Genome Research, 47(1-2), 16-17. https://doi.org/10.1159/000132496