Chromosomal localization of human lactotransferrin gene (Ltf) by in situ hybridization

J. L. McCombs; C. T. Teng; B. T. Pentecost; V. L. Magnuson; C. M. Moore; J. R. McGill

doi:10.1159/000132496

Chromosomal localization of human lactotransferrin gene (Ltf) by in situ hybridization

J. L. McCombs, C. T. Teng, B. T. Pentecost, V. L. Magnuson, C. M. Moore, J. R. McGill

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Abstract

Lactotransferrin (LTF) is an important member of the transferrin family of proteins. These proteins play an essential role in the transport of iron in extracellular fluid (Aisen and Lis-towsky. 1980). Southern blot analysis of mouse-human somatic cell hybrids have localized the LTF gene to region q21→qter of human chromosome 3 (Teng et al., unpublished data). Using the same full-length mouse cDNA probe (2.2 kb), the LTF gene was mapped to human chromosomal bands 3q21→q23 by in situ hybridization. The sublocalization of the LTF gene to 3q21→q23 is in the region of human chromosome 3 where the gene loci of transferrin and transferrin receptor have been localized (Yang et al. 1984; van dc Rijn el al. 1983).

Original language	English (US)
Pages (from-to)	16-17
Number of pages	2
Journal	Cytogenetic and Genome Research
Volume	47
Issue number	1-2
DOIs	https://doi.org/10.1159/000132496
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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title = "Chromosomal localization of human lactotransferrin gene (Ltf) by in situ hybridization",

abstract = "Lactotransferrin (LTF) is an important member of the transferrin family of proteins. These proteins play an essential role in the transport of iron in extracellular fluid (Aisen and Lis-towsky. 1980). Southern blot analysis of mouse-human somatic cell hybrids have localized the LTF gene to region q21→qter of human chromosome 3 (Teng et al., unpublished data). Using the same full-length mouse cDNA probe (2.2 kb), the LTF gene was mapped to human chromosomal bands 3q21→q23 by in situ hybridization. The sublocalization of the LTF gene to 3q21→q23 is in the region of human chromosome 3 where the gene loci of transferrin and transferrin receptor have been localized (Yang et al. 1984; van dc Rijn el al. 1983).",

author = "McCombs, {J. L.} and Teng, {C. T.} and Pentecost, {B. T.} and Magnuson, {V. L.} and Moore, {C. M.} and McGill, {J. R.}",

year = "1988",

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T1 - Chromosomal localization of human lactotransferrin gene (Ltf) by in situ hybridization

AU - McCombs, J. L.

AU - Teng, C. T.

AU - Pentecost, B. T.

AU - Magnuson, V. L.

AU - Moore, C. M.

AU - McGill, J. R.

PY - 1988

Y1 - 1988

N2 - Lactotransferrin (LTF) is an important member of the transferrin family of proteins. These proteins play an essential role in the transport of iron in extracellular fluid (Aisen and Lis-towsky. 1980). Southern blot analysis of mouse-human somatic cell hybrids have localized the LTF gene to region q21→qter of human chromosome 3 (Teng et al., unpublished data). Using the same full-length mouse cDNA probe (2.2 kb), the LTF gene was mapped to human chromosomal bands 3q21→q23 by in situ hybridization. The sublocalization of the LTF gene to 3q21→q23 is in the region of human chromosome 3 where the gene loci of transferrin and transferrin receptor have been localized (Yang et al. 1984; van dc Rijn el al. 1983).

AB - Lactotransferrin (LTF) is an important member of the transferrin family of proteins. These proteins play an essential role in the transport of iron in extracellular fluid (Aisen and Lis-towsky. 1980). Southern blot analysis of mouse-human somatic cell hybrids have localized the LTF gene to region q21→qter of human chromosome 3 (Teng et al., unpublished data). Using the same full-length mouse cDNA probe (2.2 kb), the LTF gene was mapped to human chromosomal bands 3q21→q23 by in situ hybridization. The sublocalization of the LTF gene to 3q21→q23 is in the region of human chromosome 3 where the gene loci of transferrin and transferrin receptor have been localized (Yang et al. 1984; van dc Rijn el al. 1983).

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Chromosomal localization of human lactotransferrin gene (Ltf) by in situ hybridization

Abstract

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