Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

N. K. Honey; A. Y. Sakaguchi; P. A. Lalley; C. Quinto; R. J. MacDonald; C. Craik; G. I. Bell; W. J. Rutter; S. L. Naylor

doi:10.1007/BF01535633

Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

N. K. Honey
, A. Y. Sakaguchi
, P. A. Lalley
, C. Quinto
, R. J. MacDonald
, C. Craik
, G. I. Bell
, W. J. Rutter
, S. L. Naylor

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

Original language	English (US)
Pages (from-to)	377-383
Number of pages	7
Journal	Somatic Cell and Molecular Genetics
Volume	10
Issue number	4
DOIs	https://doi.org/10.1007/BF01535633
State	Published - Jul 1984
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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10.1007/BF01535633

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title = "Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse",

abstract = "The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.",

author = "Honey, \{N. K.\} and Sakaguchi, \{A. Y.\} and Lalley, \{P. A.\} and C. Quinto and MacDonald, \{R. J.\} and C. Craik and Bell, \{G. I.\} and Rutter, \{W. J.\} and Naylor, \{S. L.\}",

year = "1984",

month = jul,

doi = "10.1007/BF01535633",

language = "English (US)",

volume = "10",

pages = "377--383",

journal = "Somatic Cell and Molecular Genetics",

issn = "0740-7750",

publisher = "Springer Science and Business Media, LLC",

number = "4",

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TY - JOUR

T1 - Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

AU - Honey, N. K.

AU - Sakaguchi, A. Y.

AU - Lalley, P. A.

AU - Quinto, C.

AU - MacDonald, R. J.

AU - Craik, C.

AU - Bell, G. I.

AU - Rutter, W. J.

AU - Naylor, S. L.

PY - 1984/7

Y1 - 1984/7

N2 - The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

AB - The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

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U2 - 10.1007/BF01535633

DO - 10.1007/BF01535633

M3 - Article

C2 - 6589791

AN - SCOPUS:0021627533

SN - 0740-7750

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EP - 383

JO - Somatic Cell and Molecular Genetics

JF - Somatic Cell and Molecular Genetics

IS - 4

ER -

Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

Abstract

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