Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

N. K. Honey; A. Y. Sakaguchi; P. A. Lalley; C. Quinto; R. J. MacDonald; C. Craik; G. I. Bell; W. J. Rutter; S. L. Naylor

doi:10.1007/BF01535633

Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

N. K. Honey, A. Y. Sakaguchi, P. A. Lalley, C. Quinto, R. J. MacDonald, C. Craik, G. I. Bell, W. J. Rutter, S. L. Naylor

Research output: Contribution to journal › Article › peer-review

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Abstract

The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

Original language	English (US)
Pages (from-to)	377-383
Number of pages	7
Journal	Somatic Cell and Molecular Genetics
Volume	10
Issue number	4
DOIs	https://doi.org/10.1007/BF01535633
State	Published - Jul 1984
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse",

abstract = "The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.",

author = "Honey, {N. K.} and Sakaguchi, {A. Y.} and Lalley, {P. A.} and C. Quinto and MacDonald, {R. J.} and C. Craik and Bell, {G. I.} and Rutter, {W. J.} and Naylor, {S. L.}",

year = "1984",

month = jul,

doi = "10.1007/BF01535633",

language = "English (US)",

volume = "10",

pages = "377--383",

journal = "Somatic Cell and Molecular Genetics",

issn = "0740-7750",

publisher = "Springer GmbH & Co, Auslieferungs-Gesellschaf",

number = "4",

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TY - JOUR

T1 - Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

AU - Honey, N. K.

AU - Sakaguchi, A. Y.

AU - Lalley, P. A.

AU - Quinto, C.

AU - MacDonald, R. J.

AU - Craik, C.

AU - Bell, G. I.

AU - Rutter, W. J.

AU - Naylor, S. L.

PY - 1984/7

Y1 - 1984/7

N2 - The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

AB - The mouse genes for the serine proteases trypsin (Try-1, chymotrypsin B (Ctrb), and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.

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Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

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