Chromosomal assignment in mouse of matrix Gla protein and bone Gla protein genes

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Abstract

Matrix Gla protein (MGLAP) and bone Gla protein (BGLAP) are calcium-binding, vitamin K-dependent proteins produced by cells of the osteoblastic lineage. Sequence homology suggests that the genes for these proteins evolved from a common ancestor. Somatic whole cell bybrids and karyotypically simple microcell hybrids were used to map Mglap to mouse Chromosome 6 and Bglap to mouse Chromosome 3. Human MGLAP has previously been mapped to chromosome 12p, a region with homology to mouse Chromosome 6, and human BGLAP has been mapped to chromosome 1q, a region with homology to mouse Chromosome 3. It appears that BGLAP is the third calcium-binding protein that maps to human chromosome 1q and mouse Chromosome 3.

Original languageEnglish (US)
Pages (from-to)770-772
Number of pages3
JournalGenomics
Volume11
Issue number3
DOIs
StatePublished - Nov 1991

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ASJC Scopus subject areas

  • Genetics

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