Chromosomal analysis of pregnancy losses in patients undergoing assisted reproduction

Larry E. Shields, Paulo C. Serafini, Robert S. Schenken, Charleen M. Moore

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Chromosomal analysis was performed on products of conception from 18 patients having early pregnancy loss after assisted reproduction. Sonographic findings prior to obtaining tissue varied from gestational sacs consistent with a blighted ovum to fetal poles with cardiac activity. The mean age of the patients was 36.3 years. There were nine (50%) normal karyotypes, five (28%) autosomal trisomies, two cases of tetraploidy, one case of monosomy, and a case with two pericentric inversions. The results of this study suggest that patients undergoing assisted reproduction are not at an increased risk for chromosomal abnormalities.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Issue number1
StatePublished - Feb 1992


  • chromosomal analysis
  • early pregnancy loss
  • in vitro fertilization

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)


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