Chromosomal aberrations in tuberculosis patients before and after treatment with short-term chemotherapy

V. V.N. Gopal Rao, E. V. Venkatarama Gupta, I. M. Thomas

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Cytogenetic effects of 4 common anti-tubercular drugs, isoniazid (H), streptomycin (S), rifampicin (R) and pyrazinamide (Z), in 3 different combinations (2 SHRZ, 2 HRZ and 2 H2R2Z2) were evaluated in the lymphocytes of tuberculosis patients undergoing chemotherapy, in order to estimate their mutagenic potential in combination. All 3 regimens showed an increased frequency of chromosomal aberrations after treatment compared to before treatment. These findings are of significance in the treatment of tuberculosis, as the drugs in question are observed to be mutagenic/clastogenic.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalMutation Research/Genetic Toxicology
Volume259
Issue number1
DOIs
StatePublished - Jan 1991
Externally publishedYes

Keywords

  • Cytogenetic effects
  • Tuberculosis chemotherapy

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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