Chromogranin A levels and mortality in patients with severe sepsis

Chih Hsin Hsu; Luis F. Reyes; Carlos J. Orihuela; Ricardo Buitrago; Antonio Anzueto; Nilam J. Soni; Stephanie Levine; Jay Peters; Cecilia A. Hinojosa; Stefano Aliberti; Oriol Sibila; Alejandro Rodriguez; James D. Chalmers; Ignacio Martin-Loeches; Jose Bordon; Jose Blanquer; Francisco Sanz; Pedro J. Marcos; Jordi Rello; Jordi Solé-Violán; Marcos I. Restrepo

doi:10.3109/1354750X.2015.1046932

Chromogranin A levels and mortality in patients with severe sepsis

Chih Hsin Hsu, Luis F. Reyes, Carlos J. Orihuela, Ricardo Buitrago, Antonio Anzueto, Nilam J. Soni, Stephanie Levine, Jay Peters, Cecilia A. Hinojosa, Stefano Aliberti, Oriol Sibila, Alejandro Rodriguez, James D. Chalmers, Ignacio Martin-Loeches, Jose Bordon, Jose Blanquer, Francisco Sanz, Pedro J. Marcos, Jordi Rello, Jordi Solé-ViolánMarcos I. Restrepo

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

Original language	English (US)
Pages (from-to)	171-176
Number of pages	6
Journal	Biomarkers
Volume	20
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2015.1046932
State	Published - Apr 3 2015

Keywords

Biological marker
Chromogranin A
cardiovascular diseases
mortality
sepsis

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2015.1046932

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Hsu, C. H., Reyes, L. F., Orihuela, C. J., Buitrago, R., Anzueto, A., Soni, N. J., Levine, S., Peters, J., Hinojosa, C. A., Aliberti, S., Sibila, O., Rodriguez, A., Chalmers, J. D., Martin-Loeches, I., Bordon, J., Blanquer, J., Sanz, F., Marcos, P. J., Rello, J., ... Restrepo, M. I. (2015). Chromogranin A levels and mortality in patients with severe sepsis. Biomarkers, 20(3), 171-176. https://doi.org/10.3109/1354750X.2015.1046932

Hsu, CH, Reyes, LF, Orihuela, CJ, Buitrago, R, Anzueto, A, Soni, NJ , Levine, S , Peters, J, Hinojosa, CA, Aliberti, S, Sibila, O, Rodriguez, A, Chalmers, JD, Martin-Loeches, I, Bordon, J, Blanquer, J, Sanz, F, Marcos, PJ, Rello, J, Solé-Violán, J & Restrepo, MI 2015, 'Chromogranin A levels and mortality in patients with severe sepsis', Biomarkers, vol. 20, no. 3, pp. 171-176. https://doi.org/10.3109/1354750X.2015.1046932

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title = "Chromogranin A levels and mortality in patients with severe sepsis",

abstract = "Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.",

keywords = "Biological marker, Chromogranin A, cardiovascular diseases, mortality, sepsis",

author = "Hsu, {Chih Hsin} and Reyes, {Luis F.} and Orihuela, {Carlos J.} and Ricardo Buitrago and Antonio Anzueto and Soni, {Nilam J.} and Stephanie Levine and Jay Peters and Hinojosa, {Cecilia A.} and Stefano Aliberti and Oriol Sibila and Alejandro Rodriguez and Chalmers, {James D.} and Ignacio Martin-Loeches and Jose Bordon and Jose Blanquer and Francisco Sanz and Marcos, {Pedro J.} and Jordi Rello and Jordi Sol{\'e}-Viol{\'a}n and Restrepo, {Marcos I.}",

note = "Funding Information: All authors have no conflict of interest. Dr. Restrepo{\textquoteright}s time is partially protected by Award Number K23HL096054 from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, And Blood Institute or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2015 Informa UK Ltd. All rights reserved.",

year = "2015",

month = apr,

day = "3",

doi = "10.3109/1354750X.2015.1046932",

language = "English (US)",

volume = "20",

pages = "171--176",

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T1 - Chromogranin A levels and mortality in patients with severe sepsis

AU - Hsu, Chih Hsin

AU - Reyes, Luis F.

AU - Orihuela, Carlos J.

AU - Buitrago, Ricardo

AU - Anzueto, Antonio

AU - Soni, Nilam J.

AU - Levine, Stephanie

AU - Peters, Jay

AU - Hinojosa, Cecilia A.

AU - Aliberti, Stefano

AU - Sibila, Oriol

AU - Rodriguez, Alejandro

AU - Chalmers, James D.

AU - Martin-Loeches, Ignacio

AU - Bordon, Jose

AU - Blanquer, Jose

AU - Sanz, Francisco

AU - Marcos, Pedro J.

AU - Rello, Jordi

AU - Solé-Violán, Jordi

AU - Restrepo, Marcos I.

N1 - Funding Information: All authors have no conflict of interest. Dr. Restrepo’s time is partially protected by Award Number K23HL096054 from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, And Blood Institute or the National Institutes of Health. Publisher Copyright: © 2015 Informa UK Ltd. All rights reserved.

PY - 2015/4/3

Y1 - 2015/4/3

N2 - Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

AB - Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

KW - Biological marker

KW - Chromogranin A

KW - cardiovascular diseases

KW - mortality

KW - sepsis

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Chromogranin A levels and mortality in patients with severe sepsis

Abstract

Keywords

ASJC Scopus subject areas

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