@article{d61026c737db47bda3f707443cbee70f,
title = "Chromogranin A levels and mortality in patients with severe sepsis",
abstract = "Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.",
keywords = "Biological marker, Chromogranin A, cardiovascular diseases, mortality, sepsis",
author = "Hsu, {Chih Hsin} and Reyes, {Luis F.} and Orihuela, {Carlos J.} and Ricardo Buitrago and Antonio Anzueto and Soni, {Nilam J.} and Stephanie Levine and Jay Peters and Hinojosa, {Cecilia A.} and Stefano Aliberti and Oriol Sibila and Alejandro Rodriguez and Chalmers, {James D.} and Ignacio Martin-Loeches and Jose Bordon and Jose Blanquer and Francisco Sanz and Marcos, {Pedro J.} and Jordi Rello and Jordi Sol{\'e}-Viol{\'a}n and Restrepo, {Marcos I.}",
note = "Funding Information: All authors have no conflict of interest. Dr. Restrepo{\textquoteright}s time is partially protected by Award Number K23HL096054 from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, And Blood Institute or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2015 Informa UK Ltd. All rights reserved.",
year = "2015",
month = apr,
day = "3",
doi = "10.3109/1354750X.2015.1046932",
language = "English (US)",
volume = "20",
pages = "171--176",
journal = "Biomarkers",
issn = "1354-750X",
publisher = "Informa Healthcare",
number = "3",
}