Chromogranin A levels and mortality in patients with severe sepsis

Chih Hsin Hsu, Luis F. Reyes, Carlos J. Orihuela, Ricardo Buitrago, Antonio Anzueto, Nilam J. Soni, Stephanie Levine, Jay Peters, Cecilia A. Hinojosa, Stefano Aliberti, Oriol Sibila, Alejandro Rodriguez, James D. Chalmers, Ignacio Martin-Loeches, Jose Bordon, Jose Blanquer, Francisco Sanz, Pedro J. Marcos, Jordi Rello, Jordi Solé-ViolánMarcos I. Restrepo

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.Objective: Assess association of CgA levels and mortality risk of severely septic patients.Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalBiomarkers
Volume20
Issue number3
DOIs
StatePublished - Apr 3 2015

Keywords

  • Biological marker
  • Chromogranin A
  • cardiovascular diseases
  • mortality
  • sepsis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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  • Cite this

    Hsu, C. H., Reyes, L. F., Orihuela, C. J., Buitrago, R., Anzueto, A., Soni, N. J., Levine, S., Peters, J., Hinojosa, C. A., Aliberti, S., Sibila, O., Rodriguez, A., Chalmers, J. D., Martin-Loeches, I., Bordon, J., Blanquer, J., Sanz, F., Marcos, P. J., Rello, J., ... Restrepo, M. I. (2015). Chromogranin A levels and mortality in patients with severe sepsis. Biomarkers, 20(3), 171-176. https://doi.org/10.3109/1354750X.2015.1046932