TY - JOUR
T1 - Choroidal thickness in normal Indian subjects using Swept source optical coherence tomography
AU - Akhtar, Zeeshan
AU - Rishi, Pukhraj
AU - Srikanth, Ramasubramanian
AU - Rishi, Ekta
AU - Bhende, Muna
AU - Raman, Rajiv
N1 - Publisher Copyright:
© 2018 Akhtar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/5
Y1 - 2018/5
N2 - Aim To determine choroidal thickness in healthy Indian subjects using Swept source optical coherence tomography (SS-OCT). Methods In this prospective, observational, cross-sectional study; healthy Indian subjects (n = 230) with no history of ocular and/or systemic disorders were enrolled in the study. Choroidal thickness was measured for 230 eyes using SS-OCT. Subjects were divided into six age groups. Main outcome measures were subfoveal choroidal thickness (SFCT) and macular choroidal thickness (MCT) up to 3 mm at 500-micron interval from the fovea was measured in eight different quadrants. Results The mean SFCT was 307±79 μm and mean MCT was 285±75 μm. No difference in the choroidal thickness was found among genders. Mean SFCT of the different age groups was 327±68 μm (12–18 years), 364±70 μm (18.1–30 years), 321±78 μm (30.1–40 years), 304± 79 μm (40.1–50 years), 283±69 μm (50.1–60 years) and 262±72μm (above 60 years; p < 0.001; One way ANOVA). Mean macular choroidal thickness was 305±60 μm, 342±61 μm, 306±72 μm, 282±79 μm, 261±66 μm, 238±68μm respectively (p<0.001; one way ANOVA). A significant weak negative correlation was found between age with SFCT (r = -0.368, p<0.001) and MCT (r = -0.40, p<0.001). No significant correlation was found with refractive error, axial length and ocular perfusion pressure. Conclusion This study showed that mean SFCT and MCT was 307±79μm and 285±75 μm, respectively, among healthy Indian subjects. Mean CT was found to decrease with age, although there was no difference in CT between genders.
AB - Aim To determine choroidal thickness in healthy Indian subjects using Swept source optical coherence tomography (SS-OCT). Methods In this prospective, observational, cross-sectional study; healthy Indian subjects (n = 230) with no history of ocular and/or systemic disorders were enrolled in the study. Choroidal thickness was measured for 230 eyes using SS-OCT. Subjects were divided into six age groups. Main outcome measures were subfoveal choroidal thickness (SFCT) and macular choroidal thickness (MCT) up to 3 mm at 500-micron interval from the fovea was measured in eight different quadrants. Results The mean SFCT was 307±79 μm and mean MCT was 285±75 μm. No difference in the choroidal thickness was found among genders. Mean SFCT of the different age groups was 327±68 μm (12–18 years), 364±70 μm (18.1–30 years), 321±78 μm (30.1–40 years), 304± 79 μm (40.1–50 years), 283±69 μm (50.1–60 years) and 262±72μm (above 60 years; p < 0.001; One way ANOVA). Mean macular choroidal thickness was 305±60 μm, 342±61 μm, 306±72 μm, 282±79 μm, 261±66 μm, 238±68μm respectively (p<0.001; one way ANOVA). A significant weak negative correlation was found between age with SFCT (r = -0.368, p<0.001) and MCT (r = -0.40, p<0.001). No significant correlation was found with refractive error, axial length and ocular perfusion pressure. Conclusion This study showed that mean SFCT and MCT was 307±79μm and 285±75 μm, respectively, among healthy Indian subjects. Mean CT was found to decrease with age, although there was no difference in CT between genders.
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U2 - 10.1371/journal.pone.0197457
DO - 10.1371/journal.pone.0197457
M3 - Article
C2 - 29768485
AN - SCOPUS:85047203588
SN - 1932-6203
VL - 13
JO - PloS one
JF - PloS one
IS - 5
M1 - e0197457
ER -