Choroidal microvascular repair after argon laser photocoagulation. Ultrastructural observations

D. D. Perry, R. L. Reddick, J. M. Risco

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaries. Early changes are characterized by the appearance of platelet-fibrin thrombin within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative changes. No endothelial cell mitotic activity is seen. The endothelial cytoplasm becomes plump, and there is a loss of the fenestrations adjacent to Bruch's membrane. By 10-20 days, the capillary structure shows gradual restoration. At 30 days, endothelial cell fenestrae are clearly evident adjacent to Bruch's membrane. The reparative process in this model appears to evolve as a result of thrombolysis and endothelial cell activation.

Original languageEnglish (US)
Pages (from-to)1019-1026
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume25
Issue number9
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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