Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaries. Early changes are characterized by the appearance of platelet-fibrin thrombin within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative changes. No endothelial cell mitotic activity is seen. The endothelial cytoplasm becomes plump, and there is a loss of the fenestrations adjacent to Bruch's membrane. By 10-20 days, the capillary structure shows gradual restoration. At 30 days, endothelial cell fenestrae are clearly evident adjacent to Bruch's membrane. The reparative process in this model appears to evolve as a result of thrombolysis and endothelial cell activation.
|Original language||English (US)|
|Number of pages||8|
|Journal||Investigative Ophthalmology and Visual Science|
|State||Published - 1984|
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience