Cholesterol metabolism in juvenile baboons: Influence of infant and juvenile diets

G. E. Mott, E. M. Jackson, C. A. McMahan, C. M. Farley, H. C. McGill

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The deferred effects of infant diets and the effects of juvenile diets on cholesterol metabolism were estimated in 83 baboons (Papio sp.) at 3.5 years of age. As infants, the animals were breast-fed or fed one of three formulas containing approximately 2, 30, or 60 mg/dl cholesterol. After weaning at 14 weeks of age, the animals were fed one of four juvenile diets high or low in cholesterol with saturated (P/S = 0.37) or unsaturated (P/S = 2.1) fats. Cholesterol absorption and cholesterol turnover were measured by fecal isotopic methods, and variables of cholesterol metabolism were estimated from a two-pool model. Among juvenile animals breast-fed during infancy, the percentage of cholesterol absorption was higher, while the fluxes of cholesterol from Pool A (Q(AA), Q(A), and Q(AB)) and the cholesterol mass of Pool B were lower, compared to those fed formulas. The level of cholesterol in formulas fed during infancy did not influence cholesterol metabolism during the juvenile period. During the juvenile period, saturated fat significantly decreased the cholesterol production rate (Q(A)) and increased the rate constants for cholesterol flux between Pool A and Pool B (K(AB) and K(BA)) compared to unsaturated fat. High cholesterol intake increased bile acid and neutral steroid excretion, cholesterol turnover rate, the mass of Pool A, and the rate constant K(A) and fluxes Q(A) and Q(AA) for removal of cholesterol from Pool A. However, K(AB), t( 1/2 )B (half-time of Pool B), and the percentage of cholesterol absorbed were decreased. Dietary cholesterol and saturated fat had similar effects on serum cholesterol and lipoprotein concentrations in these animals, but they had opposite effects on several aspects of cholesterol metabolism.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
Issue number4
StatePublished - 1985

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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