Abstract
Disposition of the circulating levels of 10 chlorpromazine metabolites and their conjugates in the blood fractions of chronic schizophrenic patients was determined. The erythrocytes were found to sequester nearly 50% of the total blood concentration of the free metabolites, whereas the platelets contained only insignificant amounts. Of particular significance was the localization of the conjugated metabolites in the red cells. The implications of sequestration of the metabolites and their conjugates by the erythrocytes are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1753-1757 |
| Number of pages | 5 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 61 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1972 |
| Externally published | Yes |
Keywords
- Blood distribution, erythrocyte sequestration—chlorpromazine metabolites, schizophrenic patients
- Chlorpromazine metabolism—disposition of free and conjugated metabolites in blood fractions of schizophrenic patients
- Erythrocyte sequestration—disposition of free and conjugated metabolites of chlorpromazine in blood of schizophrenic patients
- Schizophrenics′ chlorpromazine blood distribution—disposition of free and conjugated metabolites, erythrocyte sequestration
ASJC Scopus subject areas
- Pharmaceutical Science