Chlorpromazine metabolism V: Disposition of free and conjugated metabolites in blood fractions of schizophrenic patients

Pushkar N. Kaul, Maharaj K. Ticku, Mervin L. Clark

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Disposition of the circulating levels of 10 chlorpromazine metabolites and their conjugates in the blood fractions of chronic schizophrenic patients was determined. The erythrocytes were found to sequester nearly 50% of the total blood concentration of the free metabolites, whereas the platelets contained only insignificant amounts. Of particular significance was the localization of the conjugated metabolites in the red cells. The implications of sequestration of the metabolites and their conjugates by the erythrocytes are discussed.

Original languageEnglish (US)
Pages (from-to)1753-1757
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume61
Issue number11
DOIs
StatePublished - Nov 1972
Externally publishedYes

Keywords

  • Blood distribution, erythrocyte sequestration—chlorpromazine metabolites, schizophrenic patients
  • Chlorpromazine metabolism—disposition of free and conjugated metabolites in blood fractions of schizophrenic patients
  • Erythrocyte sequestration—disposition of free and conjugated metabolites of chlorpromazine in blood of schizophrenic patients
  • Schizophrenics′ chlorpromazine blood distribution—disposition of free and conjugated metabolites, erythrocyte sequestration

ASJC Scopus subject areas

  • Pharmaceutical Science

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