Chlorpromazine metabolism. III. Determination of conjugated metabolites in the blood of schizophrenic patients

Pushkar N. Kaul; Michael W. Conway; Maharaj K. Ticku; Mervin L. Clark

Chlorpromazine metabolism. III. Determination of conjugated metabolites in the blood of schizophrenic patients

Pushkar N. Kaul, Michael W. Conway, Maharaj K. Ticku, Mervin L. Clark

Research output: Contribution to journal › Article › peer-review

Abstract

Optimum conditions for the hydrolyses of the conjugated metabolites of chlorpromazine have been developed. Enzymatic procedure under such conditions yields 80 per cent hydrolysis in 1 hour. The rates of hydrolyses of individual metabolite conjugates have been determined. The time required for maximum hydrolysis of all the known conjugates varies between 1 and 4 hours.

Original language	English (US)
Pages (from-to)	467-475
Number of pages	9
Journal	The Journal of Laboratory and Clinical Medicine
Volume	81
Issue number	3
State	Published - Mar 1973
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine

Cite this

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title = "Chlorpromazine metabolism. III. Determination of conjugated metabolites in the blood of schizophrenic patients",

abstract = "Optimum conditions for the hydrolyses of the conjugated metabolites of chlorpromazine have been developed. Enzymatic procedure under such conditions yields 80 per cent hydrolysis in 1 hour. The rates of hydrolyses of individual metabolite conjugates have been determined. The time required for maximum hydrolysis of all the known conjugates varies between 1 and 4 hours.",

author = "Kaul, {Pushkar N.} and Conway, {Michael W.} and Ticku, {Maharaj K.} and Clark, {Mervin L.}",

year = "1973",

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AU - Clark, Mervin L.

PY - 1973/3

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AB - Optimum conditions for the hydrolyses of the conjugated metabolites of chlorpromazine have been developed. Enzymatic procedure under such conditions yields 80 per cent hydrolysis in 1 hour. The rates of hydrolyses of individual metabolite conjugates have been determined. The time required for maximum hydrolysis of all the known conjugates varies between 1 and 4 hours.

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Chlorpromazine metabolism. III. Determination of conjugated metabolites in the blood of schizophrenic patients

Abstract

ASJC Scopus subject areas

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