Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients

Pushkar N. Kaul, Michael W. Conway, Maharaj K. Ticku, Mervin L. Clark

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.

Original languageEnglish (US)
Pages (from-to)581-585
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume61
Issue number4
DOIs
StatePublished - Apr 1972
Externally publishedYes

Keywords

  • Chlorpromazine metabolism—determination of 11 nonconjugated metabolites in the blood of schizophrenic patients, TLC, fluorometry
  • Fluorometry—analysis, chlorpromazine metabolites in blood
  • Schizophrenics' chlorpromazine blood levels—determination of 11 nonconjugated metabolites, TLC, fluorometry
  • TLC—separation

ASJC Scopus subject areas

  • Pharmaceutical Science

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