Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients

Pushkar N. Kaul; Michael W. Conway; Maharaj K. Ticku; Mervin L. Clark

doi:10.1002/jps.2600610418

Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients

Pushkar N. Kaul, Michael W. Conway, Maharaj K. Ticku, Mervin L. Clark

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.

Original language	English (US)
Pages (from-to)	581-585
Number of pages	5
Journal	Journal of Pharmaceutical Sciences
Volume	61
Issue number	4
DOIs	https://doi.org/10.1002/jps.2600610418
State	Published - Apr 1972
Externally published	Yes

Keywords

Chlorpromazine metabolism—determination of 11 nonconjugated metabolites in the blood of schizophrenic patients, TLC, fluorometry
Fluorometry—analysis, chlorpromazine metabolites in blood
Schizophrenics' chlorpromazine blood levels—determination of 11 nonconjugated metabolites, TLC, fluorometry
TLC—separation

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600610418

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title = "Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients",

abstract = "A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.",

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author = "Kaul, {Pushkar N.} and Conway, {Michael W.} and Ticku, {Maharaj K.} and Clark, {Mervin L.}",

year = "1972",

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doi = "10.1002/jps.2600610418",

language = "English (US)",

volume = "61",

pages = "581--585",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "John Wiley and Sons Inc.",

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T1 - Chlorpromazine metabolism II

T2 - Determination of nonconjugated metabolites in blood of schizophrenic patients

AU - Kaul, Pushkar N.

AU - Conway, Michael W.

AU - Ticku, Maharaj K.

AU - Clark, Mervin L.

PY - 1972/4

Y1 - 1972/4

N2 - A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.

AB - A previously described dansylation method of quantitation was applied to determine the circulating levels of chlorpromazine metabolites in humans. Localization of the metabolites within the erythrocytes suggests that the whole hemolyzed blood be used for analyses. An optimum procedure of assay was developed which makes it possible, for the first time, to determine 11 metabolites in blood simultaneously. Blood level data from hospitalized chronic schizophrenic patients receiving variable doses of chlorpromazine are included.

KW - Chlorpromazine metabolism—determination of 11 nonconjugated metabolites in the blood of schizophrenic patients, TLC, fluorometry

KW - Fluorometry—analysis, chlorpromazine metabolites in blood

KW - Schizophrenics' chlorpromazine blood levels—determination of 11 nonconjugated metabolites, TLC, fluorometry

KW - TLC—separation

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DO - 10.1002/jps.2600610418

M3 - Article

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VL - 61

SP - 581

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JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 4

ER -

Chlorpromazine metabolism II: Determination of nonconjugated metabolites in blood of schizophrenic patients

Abstract

Keywords

ASJC Scopus subject areas

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