Chloride channels in the loop of Henle

W. B. Reeves, C. J. Winters, T. E. Andreoli

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Cl- transport in the loop of Henle is responsible for reclamation of 25-40% of the filtered NaCl load and for the formation of dilute urine. Our understanding of the physiologic and molecular mechanisms responsible for Cl- reabsorption in both the thin ascending limb and thick ascending limb of Henle's loop has increased greatly over the last decade. Plasma membrane Cl- channels are known to play an integral role in transcellular Cl- transport in both the thin and thick ascending limbs. This review focuses on the functional characteristics and molecular identities of these Cl- channels, as well as the role of these channels in the pathophysiology of disease.

Original languageEnglish (US)
Pages (from-to)631-645
Number of pages15
JournalAnnual review of physiology
StatePublished - 2001
Externally publishedYes


  • Bartter's syndrome
  • Chloride transport
  • ClC-K1
  • ClC-K2
  • Kidney

ASJC Scopus subject areas

  • Physiology


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