Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology

Jianlin Chen, Hongbo Zhang, Zhou Zhou, Zhangsheng Yang, Yiling Ding, Zhiguang Zhou, Edward Zhong, Bernard Arulanandam, Joel Baseman, Guangming Zhong

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The female lower genital tract is constantly exposed to microbial infection, some of which can ascend to and cause pathology such as hydrosalpinx in the upper genital tract, which can affect fertility. To understand host mechanisms for preventing upper genital tract pathology, we screened 11 inbred strains of mice for hydrosalpinx induction by C. muridarum. When examined on days 60 to 80 after intravaginal infection, the 11 strains fell into 3 groups based on their hydrosalpinx severity: CBA/J and SJL/J mice were highly susceptible with a hydrosalpinx score of 5 or greater; Balb/c, C57BL/ 6J, C57BL/10J, C3H/HeJ and C3H/HeN were susceptible with a score between 1 and ,5; NOD/ShiLtJ, DBA/1J, DBA/2J and A/ J were resistant with a score of ,1. The diverse range of mouse susceptibility to hydrosalpinx induction may reflect the varied clinical outcomes of C. trachomatis-infected women. When the 11 strains were infected via an intrauterine inoculation to bypass the requirement for ascension, higher incidence and more severe hydrosalpinges were induced in most mice, indicating that the interaction between chlamydial ascension and host control of ascension is critical for determining susceptibility to hydrosalpinx development in many mice. However, a few mouse strains resisted significant exacerbation of hydrosalpinx by intrauterine infection, indicating that these mice have evolved ascension-independent mechanisms for preventing upper genital tract pathology. Together, the above observations have demonstrated that different strains of mice can prevent upper genital tract pathology by using different mechanisms.

Original languageEnglish (US)
Article numbere0095076
JournalPLoS One
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2014

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Pathology
genitalia
Ascension
mice
Infection
infection
Inbred Strains Mice
Fertility
incidence
Incidence

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology. / Chen, Jianlin; Zhang, Hongbo; Zhou, Zhou; Yang, Zhangsheng; Ding, Yiling; Zhou, Zhiguang; Zhong, Edward; Arulanandam, Bernard; Baseman, Joel; Zhong, Guangming.

In: PLoS One, Vol. 9, No. 4, e0095076, 01.04.2014.

Research output: Contribution to journalArticle

Chen, J, Zhang, H, Zhou, Z, Yang, Z, Ding, Y, Zhou, Z, Zhong, E, Arulanandam, B, Baseman, J & Zhong, G 2014, 'Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology', PLoS One, vol. 9, no. 4, e0095076. https://doi.org/10.1371/journal.pone.0095076
Chen, Jianlin ; Zhang, Hongbo ; Zhou, Zhou ; Yang, Zhangsheng ; Ding, Yiling ; Zhou, Zhiguang ; Zhong, Edward ; Arulanandam, Bernard ; Baseman, Joel ; Zhong, Guangming. / Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology. In: PLoS One. 2014 ; Vol. 9, No. 4.
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