Abstract
This paper compares the histopathology of pneumonia due to murine Chlamydia trachomatis (MoPn, mouse pneumonitis agent) in ausceptible athymic nude mice (nu/nu), resistant heterozygous littermates (nu/+) and very resistant immunized nu/+ mice. While all groups had an early heterophil response, successful host defence correlated with the presence of large numbers of plasma cells, lymphocytes, monocytes, and lipid laden macrophages. Reticulate bodies were seen in all groups, predominantly in type I alveolar epithelial cells. By 24 hr in the immune nu/+ group, no intact organisms were visible. Optimal control of infection was thus rapid and not clearly related to heterophils. These studies show that the histopathology of chlamydial infection may be quite atypical in the immunocompromised host, mononuclear cells seem critical in host defence, and B cell activation with plasma cell infiltration is dependent on intact T cell function in this model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 399-411 |
| Number of pages | 13 |
| Journal | British Journal of Experimental Pathology |
| Volume | 68 |
| Issue number | 3 |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse. / Coalson, J. J.; Winter, V. T.; Bass, L. B.; Schachter, J.; Grubbs, B. G.; Williams, D. M.
In: British Journal of Experimental Pathology, Vol. 68, No. 3, 1987, p. 399-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse
AU - Coalson, J. J.
AU - Winter, V. T.
AU - Bass, L. B.
AU - Schachter, J.
AU - Grubbs, B. G.
AU - Williams, D. M.
PY - 1987
Y1 - 1987
N2 - This paper compares the histopathology of pneumonia due to murine Chlamydia trachomatis (MoPn, mouse pneumonitis agent) in ausceptible athymic nude mice (nu/nu), resistant heterozygous littermates (nu/+) and very resistant immunized nu/+ mice. While all groups had an early heterophil response, successful host defence correlated with the presence of large numbers of plasma cells, lymphocytes, monocytes, and lipid laden macrophages. Reticulate bodies were seen in all groups, predominantly in type I alveolar epithelial cells. By 24 hr in the immune nu/+ group, no intact organisms were visible. Optimal control of infection was thus rapid and not clearly related to heterophils. These studies show that the histopathology of chlamydial infection may be quite atypical in the immunocompromised host, mononuclear cells seem critical in host defence, and B cell activation with plasma cell infiltration is dependent on intact T cell function in this model.
AB - This paper compares the histopathology of pneumonia due to murine Chlamydia trachomatis (MoPn, mouse pneumonitis agent) in ausceptible athymic nude mice (nu/nu), resistant heterozygous littermates (nu/+) and very resistant immunized nu/+ mice. While all groups had an early heterophil response, successful host defence correlated with the presence of large numbers of plasma cells, lymphocytes, monocytes, and lipid laden macrophages. Reticulate bodies were seen in all groups, predominantly in type I alveolar epithelial cells. By 24 hr in the immune nu/+ group, no intact organisms were visible. Optimal control of infection was thus rapid and not clearly related to heterophils. These studies show that the histopathology of chlamydial infection may be quite atypical in the immunocompromised host, mononuclear cells seem critical in host defence, and B cell activation with plasma cell infiltration is dependent on intact T cell function in this model.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023255967&partnerID=8YFLogxK
M3 - Article
C2 - 3040067
AN - SCOPUS:0023255967
VL - 68
SP - 399
EP - 411
JO - International Journal of Experimental Pathology
JF - International Journal of Experimental Pathology
SN - 0959-9673
IS - 3
ER -