Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse

J. J. Coalson, V. T. Winter, L. B. Bass, J. Schachter, B. G. Grubbs, D. M. Williams

Research output: Contribution to journalArticle

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Abstract

This paper compares the histopathology of pneumonia due to murine Chlamydia trachomatis (MoPn, mouse pneumonitis agent) in ausceptible athymic nude mice (nu/nu), resistant heterozygous littermates (nu/+) and very resistant immunized nu/+ mice. While all groups had an early heterophil response, successful host defence correlated with the presence of large numbers of plasma cells, lymphocytes, monocytes, and lipid laden macrophages. Reticulate bodies were seen in all groups, predominantly in type I alveolar epithelial cells. By 24 hr in the immune nu/+ group, no intact organisms were visible. Optimal control of infection was thus rapid and not clearly related to heterophils. These studies show that the histopathology of chlamydial infection may be quite atypical in the immunocompromised host, mononuclear cells seem critical in host defence, and B cell activation with plasma cell infiltration is dependent on intact T cell function in this model.

Original languageEnglish (US)
Pages (from-to)399-411
Number of pages13
JournalBritish Journal of Experimental Pathology
Volume68
Issue number3
StatePublished - 1987

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Chlamydophila pneumoniae
Chlamydia trachomatis
Plasma Cells
Nude Mice
Pneumonia
Alveolar Epithelial Cells
Immunocompromised Host
Infection Control
Monocytes
B-Lymphocytes
Macrophages
Lymphocytes
T-Lymphocytes
Lipids
Infection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Coalson, J. J., Winter, V. T., Bass, L. B., Schachter, J., Grubbs, B. G., & Williams, D. M. (1987). Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse. British Journal of Experimental Pathology, 68(3), 399-411.

Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse. / Coalson, J. J.; Winter, V. T.; Bass, L. B.; Schachter, J.; Grubbs, B. G.; Williams, D. M.

In: British Journal of Experimental Pathology, Vol. 68, No. 3, 1987, p. 399-411.

Research output: Contribution to journalArticle

Coalson, JJ, Winter, VT, Bass, LB, Schachter, J, Grubbs, BG & Williams, DM 1987, 'Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse', British Journal of Experimental Pathology, vol. 68, no. 3, pp. 399-411.
Coalson JJ, Winter VT, Bass LB, Schachter J, Grubbs BG, Williams DM. Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse. British Journal of Experimental Pathology. 1987;68(3):399-411.
Coalson, J. J. ; Winter, V. T. ; Bass, L. B. ; Schachter, J. ; Grubbs, B. G. ; Williams, D. M. / Chlamydia trachomatis pneumonia in the immune, athymic and normal BALB mouse. In: British Journal of Experimental Pathology. 1987 ; Vol. 68, No. 3. pp. 399-411.
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