Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao; Youmin Zhong; Whitney Greene; Feng Dong; Guangming Zhong

doi:10.1128/IAI.72.9.5470-5474.2004

Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao, Youmin Zhong, Whitney Greene, Feng Dong, Guangming Zhong

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

Original language	English (US)
Pages (from-to)	5470-5474
Number of pages	5
Journal	Infection and immunity
Volume	72
Issue number	9
DOIs	https://doi.org/10.1128/IAI.72.9.5470-5474.2004
State	Published - Sep 2004

ASJC Scopus subject areas

Infectious Diseases
Parasitology
Microbiology
Immunology

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10.1128/IAI.72.9.5470-5474.2004

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title = "Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine",

abstract = "We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.",

author = "Yangming Xiao and Youmin Zhong and Whitney Greene and Feng Dong and Guangming Zhong",

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AU - Xiao, Yangming

AU - Zhong, Youmin

AU - Greene, Whitney

AU - Dong, Feng

AU - Zhong, Guangming

PY - 2004/9

Y1 - 2004/9

N2 - We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

AB - We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

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ER -

Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Abstract

ASJC Scopus subject areas

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