Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao, Youmin Zhong, Whitney Greene, Feng Dong, Guangming Zhong

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

Original languageEnglish (US)
Pages (from-to)5470-5474
Number of pages5
JournalInfection and immunity
Volume72
Issue number9
DOIs
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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