Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao; Youmin Zhong; Whitney Greene; Feng Dong; Guangming Zhong

doi:10.1128/IAI.72.9.5470-5474.2004

Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Yangming Xiao, Youmin Zhong, Whitney Greene, Feng Dong, Guangming Zhong

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

Original language	English (US)
Pages (from-to)	5470-5474
Number of pages	5
Journal	Infection and immunity
Volume	72
Issue number	9
DOIs	https://doi.org/10.1128/IAI.72.9.5470-5474.2004
State	Published - Sep 2004

ASJC Scopus subject areas

Infectious Diseases
Parasitology
Microbiology
Immunology

Access to Document

10.1128/IAI.72.9.5470-5474.2004

Cite this

@article{43a971488f584f0c83466528025812af,

title = "Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine",

abstract = "We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.",

author = "Yangming Xiao and Youmin Zhong and Whitney Greene and Feng Dong and Guangming Zhong",

year = "2004",

month = sep,

doi = "10.1128/IAI.72.9.5470-5474.2004",

language = "English (US)",

volume = "72",

pages = "5470--5474",

journal = "Infection and immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

AU - Xiao, Yangming

AU - Zhong, Youmin

AU - Greene, Whitney

AU - Dong, Feng

AU - Zhong, Guangming

PY - 2004/9

Y1 - 2004/9

N2 - We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

AB - We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

UR - http://www.scopus.com/inward/record.url?scp=4544363784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544363784&partnerID=8YFLogxK

U2 - 10.1128/IAI.72.9.5470-5474.2004

DO - 10.1128/IAI.72.9.5470-5474.2004

M3 - Article

C2 - 15322047

AN - SCOPUS:4544363784

SN - 0019-9567

VL - 72

SP - 5470

EP - 5474

JO - Infection and immunity

JF - Infection and immunity

IS - 9

ER -

Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this