Chlamydia trachomatis

Huizhou Fan, Guangming Zhong

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The obligate intracellular bacterium Chlamydia trachomatis is arguably the most common sexually transmitted bacterial pathogen worldwide and a major cause of blindness in underdeveloped countries. Urogenital chlamydial infection is mostly asymptomatic or exhibits very mild symptoms. However, if left untreated, it can result in devastating complications, with tubal factor infertility and pelvic inflammatory diseases being the most common outcomes, and ectopic pregnancy being the most dangerous consequence. Like other chlamydiae, C. trachomatis has a unique developmental cycle, which consists of two distinct cellular forms, and is accompanied by a temporal expression pattern of genes and small non-coding RNAs. C. trachomatis strains display strikingly different tissue tropisms, which correlate with a small number of genes differentially existing in their genomes. A conserved plasmid has been identified as a critical virulence factor. A long-awaited transformation system developed on the basis of the plasmid is anticipated to greatly facilitate the understanding of chlamydial biology in coming years.

Original languageEnglish (US)
Title of host publicationMolecular Medical Microbiology
Subtitle of host publicationSecond Edition
PublisherElsevier Ltd
Number of pages21
ISBN (Electronic)9780123971692
ISBN (Print)9780126775303
StatePublished - Nov 26 2014


  • Chlamydia
  • Chlamydia trachomatis
  • Ectopic pregnancy
  • Lymphogranuloma venereum
  • Pelvic inflammatory disease
  • Sexually transmitted infection
  • Trachoma
  • Tubal factor infertility

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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