Chlamydia-secreted proteins in chlamydial interactions with host cells

Guangming Zhong, Lei Lei, Siqi Gong, Chunxie Lu, Manli Qi, Ding Chen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Chlamydial interactions with host cells rely on chlamydia-secreted proteins, including preexisting and newly synthesized proteins. The preexisting proteins released from EBs participate in both chlamydial entry and intracellular survival at the early stage while the newly synthesized proteins secreted from RBs can both manipulate host cell signaling pathways and promote chlamydial reinfection. Despite the significant progresses made in the past decade, the precise mechanisms on what and how chlamydia-secreted proteins interact with host cells remain largely unknown, and will therefore still represent major research directions of the chlamydial field in the foreseeable future. Development of more effective methodologies will aid in discovery of new secretion molecules and novel mechanisms utilized in chlamydial in-teractions with host cells. The continuing accumulation of knowledge on chlamydia-secreted proteins and their mechanism of action may lead to discovery of novel prevention and therapeutic reagents for preventing and controlling chlamydial infection and pathologies.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalCurrent Chemical Biology
Volume5
Issue number1
DOIs
StatePublished - Jan 28 2011

Keywords

  • Chlamydia
  • Effectors
  • Host-pathogen interactions
  • Pathogenesis
  • Secretion

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry, medical

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