Chlamydia-Infected Cells Continue to Undergo Mitosis and Resist Induction of Apoptosis

Whitney Greene, Yangming Xiao, Yanqing Huang, Grant McClarty, Guangming Zhong

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Both anti- and proapoptotic activities have been reported to occur during chlamydial infection. To reconcile the apparent controversy, we compared host cell apoptotic responses to infection with 17 different chlamydial serovars and strains. None of the serovars caused any biologically significant apoptosis in the infected host cells. Host cells in chlamydia-infected cultures can continue to undergo DNA synthesis and mitosis. Chlamydia-infected cells are resistant to apoptosis induction, although the extent of the antiapoptotic ability varied between serovars. These observations have demonstrated that an anti- but not proapoptotic activity is the prevailing event in chlamydia-infected cultures.

Original languageEnglish (US)
Pages (from-to)451-460
Number of pages10
JournalInfection and immunity
Issue number1
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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