ChIP-chip comes of age for genome-wide functional analysis

Jiejun Wu, Laura T. Smith, Christoph Plass, Hui-ming Huang

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

In the post-genome era, attention has focused on the functions of genome sequences and how they are regulated. The emerging epigenomic changes and the interactions between cis-acting elements and protein factors may play a central role in gene regulation. To understand the crosstalk between DNA and protein on a genome-wide scale, one emerging technique, called ChIP-chip, takes the strategy of combining chromatin immunoprecipitation with microarray. This new high-throughput strategy helps screen the targets of critical transcription factors and profile the genome-wide distribution of histone modifications, which will enable the feasibility of conducting a large-scale study, such as the Human Epigenome Project.

Original languageEnglish (US)
Pages (from-to)6899-6902
Number of pages4
JournalCancer Research
Volume66
Issue number14
DOIs
StatePublished - Jul 15 2006
Externally publishedYes

Fingerprint

Genome
Histone Code
Chromatin Immunoprecipitation
Epigenomics
Proteins
Transcription Factors
DNA
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

ChIP-chip comes of age for genome-wide functional analysis. / Wu, Jiejun; Smith, Laura T.; Plass, Christoph; Huang, Hui-ming.

In: Cancer Research, Vol. 66, No. 14, 15.07.2006, p. 6899-6902.

Research output: Contribution to journalArticle

Wu, Jiejun ; Smith, Laura T. ; Plass, Christoph ; Huang, Hui-ming. / ChIP-chip comes of age for genome-wide functional analysis. In: Cancer Research. 2006 ; Vol. 66, No. 14. pp. 6899-6902.
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