ChIP-chip comes of age for genome-wide functional analysis

Jiejun Wu, Laura T. Smith, Christoph Plass, Tim H.M. Huang

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations

Abstract

In the post-genome era, attention has focused on the functions of genome sequences and how they are regulated. The emerging epigenomic changes and the interactions between cis-acting elements and protein factors may play a central role in gene regulation. To understand the crosstalk between DNA and protein on a genome-wide scale, one emerging technique, called ChIP-chip, takes the strategy of combining chromatin immunoprecipitation with microarray. This new high-throughput strategy helps screen the targets of critical transcription factors and profile the genome-wide distribution of histone modifications, which will enable the feasibility of conducting a large-scale study, such as the Human Epigenome Project.

Original languageEnglish (US)
Pages (from-to)6899-6902
Number of pages4
JournalCancer Research
Volume66
Issue number14
DOIs
StatePublished - Jul 15 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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