Abstract
In the post-genome era, attention has focused on the functions of genome sequences and how they are regulated. The emerging epigenomic changes and the interactions between cis-acting elements and protein factors may play a central role in gene regulation. To understand the crosstalk between DNA and protein on a genome-wide scale, one emerging technique, called ChIP-chip, takes the strategy of combining chromatin immunoprecipitation with microarray. This new high-throughput strategy helps screen the targets of critical transcription factors and profile the genome-wide distribution of histone modifications, which will enable the feasibility of conducting a large-scale study, such as the Human Epigenome Project.
Original language | English (US) |
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Pages (from-to) | 6899-6902 |
Number of pages | 4 |
Journal | Cancer Research |
Volume | 66 |
Issue number | 14 |
DOIs | |
State | Published - Jul 15 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research