Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22)

Timothy C. Griffin, Gail Tomlinson, Susana C. Raimondi, Claudio Sandoval, Charles F. Timmons, Cathy Rosenfield, Andrew J. Carroll, Nancy R. Schneider

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The chromosomal rearrangements t(1;19)(q23;p13.3) and t(9;22) (q34;q11.2) are independent abnormalities commonly observed in the blast cells of children with acute lymphoblastic leukemia (ALL). We report three children whose leukemic cells contained both translocations at diagnosis. The patients, two males aged 3 and 8 years and a female aged 14 years, all presented with central nervous system involvement. One patient exhibited a pre-B leukemic phenotype (cytoplasmic immunoglobulin, clg, positive), while two had an early pre-B phenotype (clg negative). All three patients received radiotherapy and multiagent chemotherapy which included an epipodophyllotoxin in two patients. Two patients suffered relapses of ALL, in both cases with disappearance of t(1;19)-containing clones but persistence of t(9;22). The two patients who received an epipodophyllotoxin as part of their chemotherapeutic regimen both developed secondary myeloid leukemia with entirely new cytogenetic findings, including abnormalities of chromosome band 11q23. These patients are the first to be described with this unusual combination of cytogenetic abnormalities.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalLeukemia
Volume6
Issue number6
StatePublished - Jun 1992
Externally publishedYes

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Podophyllotoxin
Chromosome Aberrations
Phenotype
Myeloid Leukemia
Cytogenetics
Immunoglobulins
Radiotherapy
Central Nervous System
Clone Cells
Recurrence
Drug Therapy

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Griffin, T. C., Tomlinson, G., Raimondi, S. C., Sandoval, C., Timmons, C. F., Rosenfield, C., ... Schneider, N. R. (1992). Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22). Leukemia, 6(6), 535-540.

Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22). / Griffin, Timothy C.; Tomlinson, Gail; Raimondi, Susana C.; Sandoval, Claudio; Timmons, Charles F.; Rosenfield, Cathy; Carroll, Andrew J.; Schneider, Nancy R.

In: Leukemia, Vol. 6, No. 6, 06.1992, p. 535-540.

Research output: Contribution to journalArticle

Griffin, TC, Tomlinson, G, Raimondi, SC, Sandoval, C, Timmons, CF, Rosenfield, C, Carroll, AJ & Schneider, NR 1992, 'Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22)', Leukemia, vol. 6, no. 6, pp. 535-540.
Griffin TC, Tomlinson G, Raimondi SC, Sandoval C, Timmons CF, Rosenfield C et al. Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22). Leukemia. 1992 Jun;6(6):535-540.
Griffin, Timothy C. ; Tomlinson, Gail ; Raimondi, Susana C. ; Sandoval, Claudio ; Timmons, Charles F. ; Rosenfield, Cathy ; Carroll, Andrew J. ; Schneider, Nancy R. / Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22). In: Leukemia. 1992 ; Vol. 6, No. 6. pp. 535-540.
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