Chiari I malformation: Association with seizures and developmental disabilities

Charles B. Brill, Juan Gutierrez, Mark M. Mishkin

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Chiari I malformation, a congenital abnormality in which deformed cerebellar tonsils are displaced downward through the foramen magnum, commonly presents in patients with headache or symptoms of dysfunction of the cerebellum, brain stem, and cervical spinal cord. We report 11 children with Chiari I malformation who presented with seizures and developmental delay in motor or language function with or without autistic features. To our knowledge, an association between Chiari I malformation and seizures or neurodevelopmental deficits or both has not been previously reported. We believe that Chiari I malformation should not be considered an incidental finding in these patients, but may be a marker for subtle cerebral dysgenesis. Chiari I and II malformations may constitute a complex but continuous spectrum, related to the timing and severity of a shared underlying embryologic mechanism.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalJournal of Child Neurology
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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