Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice

Janet A. Houghton, Peter J. Houghton, Alexander A. Green

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited of no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1 -triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
JournalCancer Research
Volume42
Issue number2
StatePublished - Feb 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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