Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice

Janet A. Houghton, Peter J Houghton, Alexander A. Green

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited of no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1 -triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
JournalCancer Research
Volume42
Issue number2
StatePublished - Feb 1 1982
Externally publishedYes

Fingerprint

Rhabdomyosarcoma
Heterografts
Drug Therapy
Busulfan
Neoplasms
Dactinomycin
Mitomycin
Vincristine
Doxorubicin
Cyclophosphamide
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice. / Houghton, Janet A.; Houghton, Peter J; Green, Alexander A.

In: Cancer Research, Vol. 42, No. 2, 01.02.1982, p. 535-539.

Research output: Contribution to journalArticle

Houghton, Janet A. ; Houghton, Peter J ; Green, Alexander A. / Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice. In: Cancer Research. 1982 ; Vol. 42, No. 2. pp. 535-539.
@article{88bf98556e0e4ac1ad4a38c4cdc0f881,
title = "Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice",
abstract = "Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited of no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1 -triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.",
author = "Houghton, {Janet A.} and Houghton, {Peter J} and Green, {Alexander A.}",
year = "1982",
month = "2",
day = "1",
language = "English (US)",
volume = "42",
pages = "535--539",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "2",

}

TY - JOUR

T1 - Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice

AU - Houghton, Janet A.

AU - Houghton, Peter J

AU - Green, Alexander A.

PY - 1982/2/1

Y1 - 1982/2/1

N2 - Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited of no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1 -triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.

AB - Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited of no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1 -triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.

UR - http://www.scopus.com/inward/record.url?scp=0020053845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020053845&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 535

EP - 539

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 2

ER -