Chemotherapeutic prevention studies of prostate cancer

Bob Djavan, Alexandre Zlotta, Claude Schulman, Pierre Teillac, Peter Iversen, Laurent Boccon Gibod, Georg Bartsch, Michael Marberger, Eric Klein, Louis J. Denis, E. David Crawford, Ian M. Thompson, Alan R. Kristal, Neil Fleshner

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Purpose: Despite advances in the detection and management of prostate cancer, this disease remains a major cause of morbidity and mortality in men. Increasing attention has focused on the role of chemoprevention for prostate cancer, ie the administration of agents that inhibit 1 or more steps in the natural history of prostate carcinogenesis. We review prostate cancer chemoprevention studies in Europe. Materials and Methods: Published studies were identified in a search of MEDLINE. Information about ongoing studies was provided by author access to protocols. Results: A variety of chemoprevention studies have focused on the role of dietary factors, vitamins and trace elements in prostate cancer. Some of these studies have been prospective, randomized and double-blinded, while others have used retrospective or epidemiological approaches. Large scale randomized studies are also evaluating the role of 5α-reductase inhibitors, which inhibit the conversion of testosterone to the more potent androgen dihydrotestosterone. Conclusions: Robust evidence is lacking for the value of chemopreventive agents in prostate cancer. Current evidence does suggest that vitamin E and selenium may have a role in prostate cancer chemoprevention. Data from 2 studies, 1 examining the type 1 5α-reductase selective inhibitor finasteride and the other using the dual 5α-reductase inhibitor dutasteride, will determine the benefits of androgen inhibition strategies for prostate cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)S10-S14
JournalJournal of Urology
Volume171
Issue number2 II
DOIs
StatePublished - Feb 2004

Keywords

  • Chemoprevention
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

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    Djavan, B., Zlotta, A., Schulman, C., Teillac, P., Iversen, P., Gibod, L. B., Bartsch, G., Marberger, M., Klein, E., Denis, L. J., Crawford, E. D., Thompson, I. M., Kristal, A. R., & Fleshner, N. (2004). Chemotherapeutic prevention studies of prostate cancer. Journal of Urology, 171(2 II), S10-S14. https://doi.org/10.1097/01.ju.0000108221.63466.7d