Chemotherapeutic induction of labour. A rational approach

Induction of labour, defined as stimulation of uterine contractions before the spontaneous onset of labour, is indicated when the condition of the mother or fetus precludes awaiting the onset of spontaneous labour. In current medical practice, induction of labour comprises 2 phases: cervical priming and induction of contractions. Although numerous agents have been used for cervical priming, the current standard of care is the use of intracervical or intravaginal prostaglandin E₂. The only drug currently used for induction of contractions is intravenous oxytocin. While many protocols are deemed acceptable, when required, the use of cervical priming, amniotomy and intravenous oxytocin are advocated. Utilising this approach, rapid delivery can be obtained in the majority of women.