Chemotactic responses of tumor cells to products of resorbing bone

William Orr, James Varani, Monica D. Gondek, Peter A. Ward, Gregory R. Mundy

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factor is released by a variety of agents that induce resorption of bone.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
Issue number4376
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

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