Chemotactic responses of tumor cells to products of resorbing bone

William Orr; James Varani; Monica D. Gondek; Peter A. Ward; Gregory R. Mundy

doi:10.1126/science.569363

Chemotactic responses of tumor cells to products of resorbing bone

William Orr, James Varani, Monica D. Gondek, Peter A. Ward, Gregory R. Mundy

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Abstract

To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factor is released by a variety of agents that induce resorption of bone.

Original language	English (US)
Pages (from-to)	176-179
Number of pages	4
Journal	Science
Volume	203
Issue number	4376
DOIs	https://doi.org/10.1126/science.569363
State	Published - 1979
Externally published	Yes

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title = "Chemotactic responses of tumor cells to products of resorbing bone",

abstract = "To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factor is released by a variety of agents that induce resorption of bone.",

author = "William Orr and James Varani and Gondek, {Monica D.} and Ward, {Peter A.} and Mundy, {Gregory R.}",

year = "1979",

doi = "10.1126/science.569363",

language = "English (US)",

volume = "203",

pages = "176--179",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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AU - Orr, William

AU - Varani, James

AU - Gondek, Monica D.

AU - Ward, Peter A.

AU - Mundy, Gregory R.

PY - 1979

Y1 - 1979

N2 - To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factor is released by a variety of agents that induce resorption of bone.

AB - To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factor is released by a variety of agents that induce resorption of bone.

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U2 - 10.1126/science.569363

DO - 10.1126/science.569363

M3 - Article

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AN - SCOPUS:0018350553

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VL - 203

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EP - 179

JO - Science

JF - Science

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ER -

Chemotactic responses of tumor cells to products of resorbing bone

Abstract

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