Chemoprevention of prostate cancer: The Prostate Cancer Prevention Trial

I. M. Thompson, Jr Coltman, J. Crowley

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

BACKGROUND: A variety of innovative approaches to the prevention of prostate cancer are now available, including selenium, alpha tocopherol, dietary interventions, and vitamin D. Perhaps the most promising opportunity is based upon considerable evidence that cumulative androgen exposure of the prostate contributes to the age-related risk of prostate cancer. METHODS. The Prostate Cancer Prevention Trial has completed randomization of over 18,000 healthy men to either finasteride or placebo. CONCLUSIONS. While the primary objective of this study is to determine whether finasteride can reduce the period prevalence of prostate cancer over a 7-year period, the biologic and data resources of this study will provide multiple opportunities to better understand this most common cancer in U.S. men.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalProstate
Volume33
Issue number3
DOIs
StatePublished - Dec 9 1997

Keywords

  • Chemoprevention
  • Finasteride
  • Prostate neoplasms

ASJC Scopus subject areas

  • Oncology
  • Urology

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