Chemoprevention in gastrointestinal physiology and disease. Targeting the progression of cancer with natural products: A focus on gastrointestinal cancer

Roxane Khoogar, Byung Chang Kim, Jay Morris, Michael J. Wargovich

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The last decade has witnessed remarkable progress in the utilization of natural products for the prevention and treatment of human cancer. Many agents now in the pipeline for clinical trial testing have evolved from our understanding of how human nutritional patterns account for widespread differences in cancer risk. In this review, we have focused on many of these promising agents arguing that they may provide a new strategy for cancer control: natural products once thought to be only preventive in their mode of action now are being explored for efficacy in tandem with cancer therapeutics. Natural products may reduce off-target toxicity of therapeutics while making cancers more amenable to therapy. On the horizon is the use of certain natural products, in their own right, as mitigants of late-stage cancer, a new frontier for small-molecule natural product drug discovery.

Original languageEnglish (US)
Pages (from-to)G629-G644
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume310
Issue number9
DOIs
StatePublished - May 2016

Keywords

  • Chemoprevention
  • Gastrointestinal cancer
  • Latestage cancer
  • Natural products
  • Phytoprevention

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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