Chemokines as potential markers in pediatric renal diseases

Ana Cristina Simões E Silva, André Barreto Pereira, Mauro Martins Teixeira, Antônio Lúcio Teixeira

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.

Original languageEnglish (US)
Article number278715
JournalDisease Markers
Volume2014
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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