Chemokines and diabetic wound healing

Oscar Ochoa, Francis M. Torres, Paula K Shireman

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Chemokines are critical for white blood cell recruitment to injured tissues and play an important role in normal wound healing processes. In contrast, impaired wound healing in diabetic patients is accompanied by decreased early inflammatory cell infiltration but persistence of neutrophils and macrophages in the chronic, nonhealing wounds. These changes in inflammatory cell recruitment occur in conjunction with alterations in chemokine and growth factor expression. In addition to leukocyte trafficking, many different cell types, including endothelial cells, fibroblasts, and keratinocytes, produce and respond to chemokines, and these interactions are altered in diabetic wounds. Thus, the chemokine system may have both direct and inflammatory-mediated effects on many different aspects of diabetic wound healing. The potential roles of chemokines and inflammatory or immune cells in nonhealing diabetic wounds, including impairments in growth factor expression, angiogenesis, extracellular matrix formation, and reepithelialization, are examined.

Original languageEnglish (US)
Pages (from-to)350-355
Number of pages6
JournalVascular
Volume15
Issue number6
DOIs
StatePublished - Nov 2007

Fingerprint

Chemokines
Wound Healing
Intercellular Signaling Peptides and Proteins
Wounds and Injuries
Leukocytes
Neutrophil Infiltration
Keratinocytes
Extracellular Matrix
Endothelial Cells
Fibroblasts
Macrophages

Keywords

  • Chemokines
  • Chronic wounds
  • Diabetes mellitus
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Chemokines and diabetic wound healing. / Ochoa, Oscar; Torres, Francis M.; Shireman, Paula K.

In: Vascular, Vol. 15, No. 6, 11.2007, p. 350-355.

Research output: Contribution to journalArticle

Ochoa, Oscar ; Torres, Francis M. ; Shireman, Paula K. / Chemokines and diabetic wound healing. In: Vascular. 2007 ; Vol. 15, No. 6. pp. 350-355.
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