Chemokine regulation of normal and pathologic immune responses

Kent Christopherson, Robert A Hromas

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

Chemokines are small basic proteins that are the major mediators of all leukocyte migration. There are at least 46 distinct chemokines, and 19 chemokine receptors, making it easily the largest cytokine family. Chemokines can be both beneficial and harmful, by either stimulating an appropriate immune response to microbial invasion, or by mediating pathologic tissue destruction in many types of human disease. Chemokines have been implicated in the tissue destruction seen in autoimmune diseases, atherosclerosis, allograft rejection, and neoplasia. Chemokines also play essential roles in normal lymphocyte trafficking to primary and secondary lymphoid organs for antigen presentation and lymphocyte maturation. Chemokines also regulate hematopoietic stem and progenitor cell homing and proliferation. Therefore, it is likely that chemokines will become important targets for pharmacologic intervention in a wide variety of human diseases in the future.

Original languageEnglish (US)
Pages (from-to)388-396
Number of pages9
JournalStem Cells
Volume19
Issue number5
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Chemokines
Hematopoietic Stem Cells
Lymphocytes
Chemokine Receptors
Antigen Presentation
Autoimmune Diseases
Allografts
Atherosclerosis
Leukocytes
Cell Proliferation
Cytokines
Neoplasms
Proteins

Keywords

  • Chemokine
  • Chemotaxis
  • Hematopoiesis
  • Homing
  • T cell

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Chemokine regulation of normal and pathologic immune responses. / Christopherson, Kent; Hromas, Robert A.

In: Stem Cells, Vol. 19, No. 5, 01.01.2001, p. 388-396.

Research output: Contribution to journalReview article

Christopherson, Kent ; Hromas, Robert A. / Chemokine regulation of normal and pathologic immune responses. In: Stem Cells. 2001 ; Vol. 19, No. 5. pp. 388-396.
@article{15ada73fabc4490cb96867836b633eba,
title = "Chemokine regulation of normal and pathologic immune responses",
abstract = "Chemokines are small basic proteins that are the major mediators of all leukocyte migration. There are at least 46 distinct chemokines, and 19 chemokine receptors, making it easily the largest cytokine family. Chemokines can be both beneficial and harmful, by either stimulating an appropriate immune response to microbial invasion, or by mediating pathologic tissue destruction in many types of human disease. Chemokines have been implicated in the tissue destruction seen in autoimmune diseases, atherosclerosis, allograft rejection, and neoplasia. Chemokines also play essential roles in normal lymphocyte trafficking to primary and secondary lymphoid organs for antigen presentation and lymphocyte maturation. Chemokines also regulate hematopoietic stem and progenitor cell homing and proliferation. Therefore, it is likely that chemokines will become important targets for pharmacologic intervention in a wide variety of human diseases in the future.",
keywords = "Chemokine, Chemotaxis, Hematopoiesis, Homing, T cell",
author = "Kent Christopherson and Hromas, {Robert A}",
year = "2001",
month = "1",
day = "1",
doi = "10.1634/stemcells.19-5-388",
language = "English (US)",
volume = "19",
pages = "388--396",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press",
number = "5",

}

TY - JOUR

T1 - Chemokine regulation of normal and pathologic immune responses

AU - Christopherson, Kent

AU - Hromas, Robert A

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Chemokines are small basic proteins that are the major mediators of all leukocyte migration. There are at least 46 distinct chemokines, and 19 chemokine receptors, making it easily the largest cytokine family. Chemokines can be both beneficial and harmful, by either stimulating an appropriate immune response to microbial invasion, or by mediating pathologic tissue destruction in many types of human disease. Chemokines have been implicated in the tissue destruction seen in autoimmune diseases, atherosclerosis, allograft rejection, and neoplasia. Chemokines also play essential roles in normal lymphocyte trafficking to primary and secondary lymphoid organs for antigen presentation and lymphocyte maturation. Chemokines also regulate hematopoietic stem and progenitor cell homing and proliferation. Therefore, it is likely that chemokines will become important targets for pharmacologic intervention in a wide variety of human diseases in the future.

AB - Chemokines are small basic proteins that are the major mediators of all leukocyte migration. There are at least 46 distinct chemokines, and 19 chemokine receptors, making it easily the largest cytokine family. Chemokines can be both beneficial and harmful, by either stimulating an appropriate immune response to microbial invasion, or by mediating pathologic tissue destruction in many types of human disease. Chemokines have been implicated in the tissue destruction seen in autoimmune diseases, atherosclerosis, allograft rejection, and neoplasia. Chemokines also play essential roles in normal lymphocyte trafficking to primary and secondary lymphoid organs for antigen presentation and lymphocyte maturation. Chemokines also regulate hematopoietic stem and progenitor cell homing and proliferation. Therefore, it is likely that chemokines will become important targets for pharmacologic intervention in a wide variety of human diseases in the future.

KW - Chemokine

KW - Chemotaxis

KW - Hematopoiesis

KW - Homing

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=0034816662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034816662&partnerID=8YFLogxK

U2 - 10.1634/stemcells.19-5-388

DO - 10.1634/stemcells.19-5-388

M3 - Review article

C2 - 11553847

AN - SCOPUS:0034816662

VL - 19

SP - 388

EP - 396

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 5

ER -