Chemokine receptors and molecular mimicry

Sunil K. Ahuja, Ji Liang Gao, Philip M. Murphy

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

Chemokines are small pro-inflammatory peptides that are best known for their leukocyte-chemoattractant activity. The cloned leukocyte chemokine receptors, interleukin 8 receptor (IL-8R) types A and B and the macrophage inflammatory protein 1α (MIP-1α/RANTES receptor, are related by sequence and chemokine binding to two herpesvirus products, and to the Duffy antigen that mediates erythrocyte invasion by the malaria-causingg parasite H smodium vivax. Here, Sunil Abuja, Ji-Liang Gao and Philip Murphy suggest that in addition to the activation of leukocytes, chemokines may be important in the function of erythrocytes and, through molecular mimicry, in microbial pathogenesis.

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalImmunology today
Volume15
Issue number6
DOIs
StatePublished - Jun 1994

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ASJC Scopus subject areas

  • Immunology

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