Abstract
Chemokines are small pro-inflammatory peptides that are best known for their leukocyte-chemoattractant activity. The cloned leukocyte chemokine receptors, interleukin 8 receptor (IL-8R) types A and B and the macrophage inflammatory protein 1α (MIP-1α/RANTES receptor, are related by sequence and chemokine binding to two herpesvirus products, and to the Duffy antigen that mediates erythrocyte invasion by the malaria-causingg parasite H smodium vivax. Here, Sunil Abuja, Ji-Liang Gao and Philip Murphy suggest that in addition to the activation of leukocytes, chemokines may be important in the function of erythrocytes and, through molecular mimicry, in microbial pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-287 |
| Number of pages | 7 |
| Journal | Immunology Today |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1994 |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Chemokine receptors and molecular mimicry. / Ahuja, Sunil K; Gao, Ji Liang; Murphy, Philip M.
In: Immunology Today, Vol. 15, No. 6, 1994, p. 281-287.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemokine receptors and molecular mimicry
AU - Ahuja, Sunil K
AU - Gao, Ji Liang
AU - Murphy, Philip M.
PY - 1994
Y1 - 1994
N2 - Chemokines are small pro-inflammatory peptides that are best known for their leukocyte-chemoattractant activity. The cloned leukocyte chemokine receptors, interleukin 8 receptor (IL-8R) types A and B and the macrophage inflammatory protein 1α (MIP-1α/RANTES receptor, are related by sequence and chemokine binding to two herpesvirus products, and to the Duffy antigen that mediates erythrocyte invasion by the malaria-causingg parasite H smodium vivax. Here, Sunil Abuja, Ji-Liang Gao and Philip Murphy suggest that in addition to the activation of leukocytes, chemokines may be important in the function of erythrocytes and, through molecular mimicry, in microbial pathogenesis.
AB - Chemokines are small pro-inflammatory peptides that are best known for their leukocyte-chemoattractant activity. The cloned leukocyte chemokine receptors, interleukin 8 receptor (IL-8R) types A and B and the macrophage inflammatory protein 1α (MIP-1α/RANTES receptor, are related by sequence and chemokine binding to two herpesvirus products, and to the Duffy antigen that mediates erythrocyte invasion by the malaria-causingg parasite H smodium vivax. Here, Sunil Abuja, Ji-Liang Gao and Philip Murphy suggest that in addition to the activation of leukocytes, chemokines may be important in the function of erythrocytes and, through molecular mimicry, in microbial pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0028216387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028216387&partnerID=8YFLogxK
U2 - 10.1016/0167-5699(94)90008-6
DO - 10.1016/0167-5699(94)90008-6
M3 - Article
C2 - 8068175
AN - SCOPUS:0028216387
VL - 15
SP - 281
EP - 287
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 6
ER -