Chemokine profile in the sera and urine of patients with schistosomal glomerulopathy

Alba Otoni, Antônio Lúcio Teixeira, Izabela Voieta, Carlos Maurićio Antunes, Vinícius Lins Costa Melo, Sandra Costa Drummond, Valério Ladeira Rodrigues, José Roberto Lambertucci

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We investigated the serum and urine chemokine levels of patients with schistosomal mansoni glomerulonephritis. This cross-sectional study was conducted in the Southeast of Brazil. Overall, 160 subjects were enrolled and divided into five groups: 1) hepatosplenic schistosomiasis with renal disease (N = 12); 2) hepatosplenic schistosomiasis without renal disease (N = 68); 3) hepatointestinal schistosomiasis (N = 27); 4) glomerulopathy caused by other diseases (N = 22); and 5) healthy controls (N = 31). The patients withmicroalbuminuria > 30 mg in 24 hours were considered to have renal disease. The sera and urine chemokines CCL2, CCL3, CCL5, CCL11, and CXCL8 were measured using an enzyme-linked immunosorbent assay test. A similar profile was observed between the patients with schistosomal glomerulopathy and the patients with glomerulopathy caused by other diseases, with the exception of serum CCL2 ≤ 634.3 pg/mL. In cases with sera CCL2 > 634.3 pg/mL, the diagnosis of schistosomal glomerulopathy should be considered.

Original languageEnglish (US)
Pages (from-to)48-53
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number1
StatePublished - Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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