Characterizing atherosclerotic plaque with computed tomography: A contrast-detail study

Nim Kasraiea, Geoffrey David Clarke

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Plaque characterization may benefit from the increasing distinctiveness of the attenuating properties of different soft plaque components at lower energies. Due to the relative slight increase in the CT number of the nonadipose soft plaque at lower tube voltage settings vs. adipose plaque, a higher contrast between atheromous adipose and non-adipose plaque may become visible with modern 64 slice systems. A contrast-detail (C-D) phantom with varying plaque composition as the contrast generating method, was imaged on a commercial 64 slice MDCT system using 80, 120, and 140 kVp settings. The same phantom was also imaged on a Cone Beam CT (CBCT) system with a lower tube voltage of 75 kVp. The results of experiments from four different observers on three different plaque types (lipid, fiber, calcific) indicate that CT attenuation within lipid cores and fibrous masses vary not only with the percentage of lipid or fiber present, but also with the size of the cores. Furthermore, the C-D curve analysis for all three plaque types reveals that while the noise constraints prevent visible differentiation of soft plaque at current conventional 64 slice MDCT settings, CBCT exhibits superior visible contrast detectability than its conventional counterpart, with the latter having appreciably better resolution limits and beneficial lower tube voltages. This low voltage CT technique has the potential to be useful in composition based diagnosis of carotid vulnerable atherosclerotic plaque.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2012
Subtitle of host publicationImage Perception, Observer Performance, and Technology Assessment
EditorsCraig K. Abbey, Claudia R. Mello-Thoms
ISBN (Electronic)9780819489678
StatePublished - 2012
EventMedical Imaging 2012: Image Perception, Observer Performance, and Technology Assessment - San Diego, United States
Duration: Feb 8 2012Feb 9 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2012: Image Perception, Observer Performance, and Technology Assessment
Country/TerritoryUnited States
CitySan Diego


  • Atherosclerosis
  • Cone beam CT
  • Contrast-detail
  • Phantom
  • Plaque

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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