Abstract
Background: Rdh54 is a motor protein that is able to dissociate Rad51 recombinase from chromatin. Results: The Rad51-binding domain of Rdh54 resides within its N terminus and is required for Rad51 removal from DNA. Conclusion: Rdh54-Rad51 interaction is important for Rad51 dissociation from chromatin but not for DNA repair. Significance: Rdh54 inhibits accumulation of toxic Rad51-DNA complexes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21999-22005 |
| Number of pages | 7 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 30 |
| DOIs | |
| State | Published - Jul 26 2013 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Fingerprint
Dive into the research topics of 'Characterization of the interaction between the saccharomyces cerevisiae Rad51 recombinase and the DNA translocase Rdh54'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS