TY - JOUR
T1 - Characterization of rat liver subcellular membranes
T2 - Demonstration of membrane-specific autoantigens
AU - Deheer, David H.
AU - Olson, Merle S.
AU - Neal Pinckard, R.
PY - 1974/2/1
Y1 - 1974/2/1
N2 - The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective absorption procedures it was demonstrated that each subcellular membrane fraction possessed unique autoantigenic activity with little or no cross-reactivity between the various membrane fractions. It is proposed that the development of membrane-specific autoantibodies may provide an immunological marker useful in the differential characterization of various subcellular membranes.
AB - The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective absorption procedures it was demonstrated that each subcellular membrane fraction possessed unique autoantigenic activity with little or no cross-reactivity between the various membrane fractions. It is proposed that the development of membrane-specific autoantibodies may provide an immunological marker useful in the differential characterization of various subcellular membranes.
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U2 - 10.1083/jcb.60.2.460
DO - 10.1083/jcb.60.2.460
M3 - Article
C2 - 4813214
AN - SCOPUS:0015987093
SN - 0021-9525
VL - 60
SP - 460
EP - 472
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 2
ER -