Characterization of pinealectomy induced convulsions in the Mongolian gerbil (Meriones unguiculatus)

R. Philo, Russel J Reiter

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The Mongolian gerbil (Meriones unguiculatus) exhibits convulsions after pinealectomy (PX). Included in the convulsions are wild running, tonic - clonic activity, and occasionally death. This paper reports various parameters that influence the convulsions. Animals 60 and 90 days old have a shorter latency to onset of convulsions than do 30-day-old gerbils. Animals pinealectomized at the onset of light (0600) in an LD 14:10 photoperiod have a shorter latency to onset and greater number of convulsions than animals pinealectomized at other times. Modulation of the photoperiod to LD 20:4 and 4:20 does not affect the convulsions. Superior cervical ganglionectomy (SCGX) does not result in convulsions; subsequent PX of the SCGX animals does. Replacement of pineal extract does not prevent the convulsions. The PX induced convulsion in gerbils resembles the parathyroidectomy-pinealectomy induced convulsion in the rat in all aspects, but with a shorter latency to onset.

Original languageEnglish (US)
Pages (from-to)485-492
Number of pages8
JournalEpilepsia
Volume19
Issue number5
StatePublished - 1978

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Gerbillinae
Seizures
Photoperiod
Ganglionectomy
Parathyroidectomy
Running
Light

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Characterization of pinealectomy induced convulsions in the Mongolian gerbil (Meriones unguiculatus). / Philo, R.; Reiter, Russel J.

In: Epilepsia, Vol. 19, No. 5, 1978, p. 485-492.

Research output: Contribution to journalArticle

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