Characterization of glucose metabolism in youth with vs. without cystic fibrosis liver disease: A pilot study

Maria Socorro Rayas, Kara S. Hughan, Rida Javaid, Andrea Kelly, Marzieh Salehi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Diabetes and liver disease are life-threatening complications of cystic fibrosis (CF). CF-liver disease is a risk factor for CF related diabetes (CFRD) development, but the underlying mechanisms linking the two co-morbidities are not known. The objective of this pilot study was to characterize glucose metabolism in youth with CF with and without liver disease. Methods: In this two-center cross-sectional study, 20 youth with CF with and without liver disease underwent a 3-hour oral glucose tolerance test. Subjects were categorized by liver disease (LD) status [no LD, mild LD, severe LD] and diabetes status. Measures of glucose excursion, islet cell secretory responses, insulin sensitivity and clearance were obtained. Results: Participants with severe LD had the highest fasting, peak, and glucose area under the curve over 3 h (AUC3h) among individuals with CFRD (interaction p < 0.05). In parallel with glycemic changes, prandial β-cell secretory response (AUC C-peptide 3h) was lower in those with severe LD compared to mild or no LD (p < 0.01). There was a trend of higher HOMA-IR in those with severe LD (p = 0.1) as well as lower fasting insulin clearance in those with mild and severe LD compared to no LD (p = 0.06) and lower prandial insulin clearance in severe LD among those with CFRD (interaction p = 0.1). Conclusion: In this small cohort, subjects with severe LD tended to have more impaired glycemia, insulin secretion, insulin sensitivity and clearance. Larger studies are imperative to define the pathogenesis to inform clinical care guidelines in terms of CFRD screening, diagnosis, and treatment options.

Original languageEnglish (US)
Article number100296
JournalJournal of Clinical and Translational Endocrinology
Volume28
DOIs
StatePublished - Jun 2022

Keywords

  • Cystic fibrosis
  • Diabetes
  • Hepatic insulin clearance
  • Insulin resistance
  • Liver disease
  • Oral glucose tolerance test

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint

Dive into the research topics of 'Characterization of glucose metabolism in youth with vs. without cystic fibrosis liver disease: A pilot study'. Together they form a unique fingerprint.

Cite this