Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp

David L. Rainwater; G. Scott Manis; Rampratap S. Kushwaha

doi:10.1016/0005-2760(86)90120-7

Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp

David L. Rainwater, G. Scott Manis, Rampratap S. Kushwaha

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

An unusual lipoprotein was detected and purified from the blood of some members of a large colony of baboons, Papio sp. This lipoprotein was found to be similar to human lipoprotein a in all respects and is therefore termed lipoprotein a. Baboon lipoprotein a had a density of 1.052 g/ml and was located between low- and high-density lipoproteins in a density gradient ultracentrifugation. However, despite its greater density, baboon lipoprotein a was larger than low-density lipoprotein, based on gradient gel electrophoresis and gel filtration. The lipoprotein contained a very large apolipoprotein (apolipoprotein-lipoprotein a) which was found to consist of an apolipoprotein B linked to another protein called apolipoprotein a by a disulfide bridge(s). In all these characteristics, baboon lipoprotein a was similar to human lipoprotein a.

Original language	English (US)
Pages (from-to)	75-78
Number of pages	4
Journal	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume	877
Issue number	1
DOIs	https://doi.org/10.1016/0005-2760(86)90120-7
State	Published - Jun 11 1986
Externally published	Yes

Keywords

(Baboon)
Apolipoprotein a
Lipoprotein a

ASJC Scopus subject areas

Biophysics
Biochemistry
Endocrinology

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10.1016/0005-2760(86)90120-7

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title = "Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp",

abstract = "An unusual lipoprotein was detected and purified from the blood of some members of a large colony of baboons, Papio sp. This lipoprotein was found to be similar to human lipoprotein a in all respects and is therefore termed lipoprotein a. Baboon lipoprotein a had a density of 1.052 g/ml and was located between low- and high-density lipoproteins in a density gradient ultracentrifugation. However, despite its greater density, baboon lipoprotein a was larger than low-density lipoprotein, based on gradient gel electrophoresis and gel filtration. The lipoprotein contained a very large apolipoprotein (apolipoprotein-lipoprotein a) which was found to consist of an apolipoprotein B linked to another protein called apolipoprotein a by a disulfide bridge(s). In all these characteristics, baboon lipoprotein a was similar to human lipoprotein a.",

keywords = "(Baboon), Apolipoprotein a, Lipoprotein a",

author = "Rainwater, {David L.} and Manis, {G. Scott} and Kushwaha, {Rampratap S.}",

note = "Funding Information: This work was supported in part by grants from the National Institutes of Health (HL 28972 and NHLBI Contract No. HV 53030) and the American Heart Association, Texas Affiliate, Inc. (85G-604), and a gift from Mrs. Betty Roberts Kelso. The authors would like to thank Drs. G.E. Mott for apolipoprotein measurements, M.-L. Cheng for gradient gel electrophoresis, and R.M. Sharp for the monoclonal antibody against baboon apolipoprotein B.",

year = "1986",

month = jun,

day = "11",

doi = "10.1016/0005-2760(86)90120-7",

language = "English (US)",

volume = "877",

pages = "75--78",

journal = "BBA - Specialised Section On Lipids and Related Subjects",

issn = "1388-1981",

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number = "1",

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T1 - Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp

AU - Rainwater, David L.

AU - Manis, G. Scott

AU - Kushwaha, Rampratap S.

N1 - Funding Information: This work was supported in part by grants from the National Institutes of Health (HL 28972 and NHLBI Contract No. HV 53030) and the American Heart Association, Texas Affiliate, Inc. (85G-604), and a gift from Mrs. Betty Roberts Kelso. The authors would like to thank Drs. G.E. Mott for apolipoprotein measurements, M.-L. Cheng for gradient gel electrophoresis, and R.M. Sharp for the monoclonal antibody against baboon apolipoprotein B.

PY - 1986/6/11

Y1 - 1986/6/11

N2 - An unusual lipoprotein was detected and purified from the blood of some members of a large colony of baboons, Papio sp. This lipoprotein was found to be similar to human lipoprotein a in all respects and is therefore termed lipoprotein a. Baboon lipoprotein a had a density of 1.052 g/ml and was located between low- and high-density lipoproteins in a density gradient ultracentrifugation. However, despite its greater density, baboon lipoprotein a was larger than low-density lipoprotein, based on gradient gel electrophoresis and gel filtration. The lipoprotein contained a very large apolipoprotein (apolipoprotein-lipoprotein a) which was found to consist of an apolipoprotein B linked to another protein called apolipoprotein a by a disulfide bridge(s). In all these characteristics, baboon lipoprotein a was similar to human lipoprotein a.

AB - An unusual lipoprotein was detected and purified from the blood of some members of a large colony of baboons, Papio sp. This lipoprotein was found to be similar to human lipoprotein a in all respects and is therefore termed lipoprotein a. Baboon lipoprotein a had a density of 1.052 g/ml and was located between low- and high-density lipoproteins in a density gradient ultracentrifugation. However, despite its greater density, baboon lipoprotein a was larger than low-density lipoprotein, based on gradient gel electrophoresis and gel filtration. The lipoprotein contained a very large apolipoprotein (apolipoprotein-lipoprotein a) which was found to consist of an apolipoprotein B linked to another protein called apolipoprotein a by a disulfide bridge(s). In all these characteristics, baboon lipoprotein a was similar to human lipoprotein a.

KW - (Baboon)

KW - Apolipoprotein a

KW - Lipoprotein a

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AN - SCOPUS:0022444219

SN - 1388-1981

VL - 877

SP - 75

EP - 78

JO - BBA - Specialised Section On Lipids and Related Subjects

JF - BBA - Specialised Section On Lipids and Related Subjects

IS - 1

ER -

Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp

Abstract

Keywords

ASJC Scopus subject areas

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