Characterization of an unusual lipoprotein similar to human lipoprotein a isolated from the baboon, Papio sp

David L. Rainwater, G. Scott Manis, Rampratap S. Kushwaha

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations

    Abstract

    An unusual lipoprotein was detected and purified from the blood of some members of a large colony of baboons, Papio sp. This lipoprotein was found to be similar to human lipoprotein a in all respects and is therefore termed lipoprotein a. Baboon lipoprotein a had a density of 1.052 g/ml and was located between low- and high-density lipoproteins in a density gradient ultracentrifugation. However, despite its greater density, baboon lipoprotein a was larger than low-density lipoprotein, based on gradient gel electrophoresis and gel filtration. The lipoprotein contained a very large apolipoprotein (apolipoprotein-lipoprotein a) which was found to consist of an apolipoprotein B linked to another protein called apolipoprotein a by a disulfide bridge(s). In all these characteristics, baboon lipoprotein a was similar to human lipoprotein a.

    Original languageEnglish (US)
    Pages (from-to)75-78
    Number of pages4
    JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
    Volume877
    Issue number1
    DOIs
    StatePublished - Jun 11 1986

    Keywords

    • (Baboon)
    • Apolipoprotein a
    • Lipoprotein a

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Endocrinology

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