Characterization of a cross-reactive idiotype on two human autoantibodies associated with systemic autoimmune disease

F. DeKeyser; M. Takei; H. Dang; H. DeKeyser; D. A. Isenberg; N. Talal

doi:10.1006/clin.1993.1164

Characterization of a cross-reactive idiotype on two human autoantibodies associated with systemic autoimmune disease

F. DeKeyser, M. Takei, H. Dang, H. DeKeyser, D. A. Isenberg, N. Talal

Developmental Dentistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A human-human hybridoma was derived from a patient with primary Sjogren’s Syndrome. The monoclonal antibody from this hybridoma, P36, was found to be polyreactive. P36 shared idiotypic cross-reactivity with a lupus-associated monoclonal antibody called 4B4. There was a strong correlation between P36 and 4B4 idiotype levels in systemic lupus erythematosus sera. Western blot studies showed that this shared idiotype was found on the heavy chain of both antibodies. This study shows that the heavy chain is important in the expression of this idiotype and provides another immunologic link between these two rheumatic diseases.

Original language	English (US)
Pages (from-to)	155-160
Number of pages	6
Journal	Clinical Immunology and Immunopathology
Volume	69
Issue number	2
DOIs	https://doi.org/10.1006/clin.1993.1164
State	Published - Nov 1993

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

Access to Document

10.1006/clin.1993.1164

Fingerprint Dive into the research topics of 'Characterization of a cross-reactive idiotype on two human autoantibodies associated with systemic autoimmune disease'. Together they form a unique fingerprint.

Cite this

@article{2d10cb7d4f0743fbafe08840682af32b,

title = "Characterization of a cross-reactive idiotype on two human autoantibodies associated with systemic autoimmune disease",

abstract = "A human-human hybridoma was derived from a patient with primary Sjogren{\textquoteright}s Syndrome. The monoclonal antibody from this hybridoma, P36, was found to be polyreactive. P36 shared idiotypic cross-reactivity with a lupus-associated monoclonal antibody called 4B4. There was a strong correlation between P36 and 4B4 idiotype levels in systemic lupus erythematosus sera. Western blot studies showed that this shared idiotype was found on the heavy chain of both antibodies. This study shows that the heavy chain is important in the expression of this idiotype and provides another immunologic link between these two rheumatic diseases.",

author = "F. DeKeyser and M. Takei and H. Dang and H. DeKeyser and Isenberg, {D. A.} and N. Talal",

year = "1993",

month = nov,

doi = "10.1006/clin.1993.1164",

language = "English (US)",

volume = "69",

pages = "155--160",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Characterization of a cross-reactive idiotype on two human autoantibodies associated with systemic autoimmune disease

AU - DeKeyser, F.

AU - Takei, M.

AU - Dang, H.

AU - DeKeyser, H.

AU - Isenberg, D. A.

AU - Talal, N.

PY - 1993/11

Y1 - 1993/11

N2 - A human-human hybridoma was derived from a patient with primary Sjogren’s Syndrome. The monoclonal antibody from this hybridoma, P36, was found to be polyreactive. P36 shared idiotypic cross-reactivity with a lupus-associated monoclonal antibody called 4B4. There was a strong correlation between P36 and 4B4 idiotype levels in systemic lupus erythematosus sera. Western blot studies showed that this shared idiotype was found on the heavy chain of both antibodies. This study shows that the heavy chain is important in the expression of this idiotype and provides another immunologic link between these two rheumatic diseases.

AB - A human-human hybridoma was derived from a patient with primary Sjogren’s Syndrome. The monoclonal antibody from this hybridoma, P36, was found to be polyreactive. P36 shared idiotypic cross-reactivity with a lupus-associated monoclonal antibody called 4B4. There was a strong correlation between P36 and 4B4 idiotype levels in systemic lupus erythematosus sera. Western blot studies showed that this shared idiotype was found on the heavy chain of both antibodies. This study shows that the heavy chain is important in the expression of this idiotype and provides another immunologic link between these two rheumatic diseases.

UR - http://www.scopus.com/inward/record.url?scp=0027373519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027373519&partnerID=8YFLogxK

U2 - 10.1006/clin.1993.1164

DO - 10.1006/clin.1993.1164

M3 - Article

C2 - 7691456

AN - SCOPUS:0027373519

VL - 69

SP - 155

EP - 160

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 2

ER -

Characterization of a cross-reactive idiotype on two human autoantibodies associated with systemic autoimmune disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this